octreotide


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octreotide

 [ok-tre´o-tīd]
a synthetic analogue of somatostatin, used as the acetate ester in palliative treatment of symptoms of gastrointestinal endocrine tumors and in treatment of acromegaly; administered subcutaneously, intragluteally, or intravenously.

oc·tre·o·tide

(ok'trē-ō-tīd),
Somatostatin analogue used to treat secretory diarrheal states and gastrointestinal bleeding.

octreotide

An hormone inhibitor analogue of the natural substance SOMATOSTATIN. Octreotide has a much longer effective time of action than somatostatin and is selective in its action on secretion of growth hormone, GASTRIN, SECRETIN and MOTILIN. It is also effective against various tumours of the ENDOCRINE system. A brand name is Sandostatin.
References in periodicals archive ?
"In the CHIASMA OPTIMAL trial, 75% of the patients randomized to the octreotide capsules treatment arm completed the 36-week trial on study drug, and 90% of those patients voluntarily elected to continue into the open label extension.
Camurus (STO: CAMX), a commercial stage biopharmaceutical company specialising in long-acting medicines for severe and chronic disorders, announced on Thursday that the US Food and Drug Administration (FDA) has accepted an Investigational New Drug (IND) application to initiate a phase 3 study with CAM2029 once-monthly octreotide subcutaneous depot for treatment of acromegaly.
Successful inhibition of meningioma cell growth was achieved in-vitro with somatostatin use and was reported more than 30 years ago.6 In order to learn its efficacy in human subjects Johnson and his colleagues conducted a phase II randomized controlled trial to study the efficacy of subcutaneous octreotide (somatostatin analogue) in recurrent meningioma and haemangiopericytoma.
Octreotide, which is a synthetic cyclic octapeptide, is a somatostatin analogue.
We herein share a clinically diagnosed intestinal lymphangiectasia case responding well to octreotide.
An abdominal radiograph (figure 1), computed tomography (CT) without contrast of the abdomen and pelvis (figure 2), and a wholebody octreotide scan (figure 3) were ordered.
Historically the treatment of severe, diffuse CHI, unresponsive to diazoxide and octreotide was subtotal pancreatectomy.
Objective: To compare the efficacy of terlipressin versus octreotide after endoscopic variceal band ligation (EVL) in prevention of early variceal rebleed.
Patient was started on intravenous octreotide therapy (5 [micro]g [kg.sup.-1] twice a day).
Somatostatin analogues such as octreotide have been reported to improve the symptoms of carcinoid syndrome [3].
This study aimed to evaluate short-term preoperative octreotide (OCT) use in TSHoma patients and to investigate SSTR2 and SSTR5 expression and observe structural changes in tumor tissue.