In this paper, the authors showed that the administration of octapressin, a vasopressin analogue, was able to improve renal function only in those patients in whom the drug increased a very low mean arterial pressure, thus establishing the relationship between effective blood volume and glomerular filtration rate in cirrhosis.
[4.] Kew MC, Varma RR, Sampson DJ, Sherlock S.The effect of octapressin on renal and intrarenal blood flow in cirrhosis of the liver.
Octapressin, a vasoconstrictor agent, does not cause significant alterations in heart rate, but its vasoconstrictor action is lower than epinephrine (3-6).
The unique study compares electrocardiographic changes in a sedated cardiac patient exposed to oral operation under local anesthesia with lidocaine alone, epinephrine-combined lidocaine and prilocaine with octapressin in the same patient.
The differences between pure lidocaine with lidocaine+epinephrine and prilocaine with octapressin were significant (Table 3, 4).
There were no significant differences between 3.6 mL of 3% prilocaine with octapressin, 3.6 mL of 2% lidocaine with 1:80.000 epinephrine and 3.6 mL of 2% lidocaine without a vasoconstrictor for ST segment deviation variable (Table 5).
The present study compared the electrocardiographic effects of lidocaine, lidocaine with epinephrine and prilocaine with octapressin in the same high risk sedated cardiac patient according to the National Cholesterol Education Programme, Adult Treatment Panel III (NCEP ATP 3) guidelines and low risk according to European Society of Cardiology ESC) guidelines during oral surgery under local anesthesia.
As shown in table 3 and 4, we found a significant difference in terms of the mean numbers of total extra systoles and isolated ectopic beats between pure lidocaine with lidocaine + epinephrine and prilocaine with octapressin were significant in the second hour following the injection.