ochronosis


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ochronosis

 [ok″ro-no´sis]
a peculiar discoloration of body tissues caused by deposit of alkapton bodies as the result of a metabolic disorder.
ocular ochronosis brown or gray discoloration of the sclera, sometimes involving also the conjunctivae and eyelids.

o·chron·o·sis

(ō'kron-ō'sis),
A rare, autosomal recessive disease characterized by alkaptonuria with pigmentation of the cartilages and sometimes tissues such as muscle, epithelial cells, and dense connective tissue; may affect also the sclera, mucous membrane of the lips, and skin of the ears, face, and hands, and cause standing urine to be dark colored and contain pigmented casts; pigmentation is thought to result from oxidized homogentisic acid, and cartilage degeneration results in osteoarthritis, particularly of the spine.
[G. ōchros, pale yellow, + nosos, disease]

ochronosis

Alkaptonuria, see there.

o·chro·no·sis

(ō'kron-ō'sis)
A condition observed in people with alkaptonuria, characterized by pigmentation of the cartilages; also may affect the sclerae, mucous membrane of the lips, and skin of the ears, face, and hands and may cause standing urine to be dark and contain pigmented casts; pigmentation results from oxidized homogentisic acid; cartilage degeneration results in osteoarthritis.
[G. ōchros, pale yellow, + nosos, disease]

ochronosis

Persistent joint disease associated with blue or brownish discoloration of the joint cartilages occurring in patients with ALKAPTONURIA.

ochronosis

People with this rare hereditary condition tend to develop arthritis in adulthood.
Mentioned in: Pseudogout
References in periodicals archive ?
It has also been shown that tissue turnover in the cartilage may be affected by ochronosis, and that this may play a role in disease initiation and progression.
Ochronosis in differential diagnosis of patients with chronic backache: a review of the literature.
Ochronosis is a syndrome caused by the accumulation of homogentisic acid (HGA) in connective tissues.
It has been suggested that the delayed appearance of ochronosis is associated with decreased renal clearance of HGA with aging.[sup][2]
Lorenzini et al., "Alkaptonuria, ochronosis, and ochronotic arthropathy," Seminars in Arthritis and Rheumatism, vol.
Alkaptonuric ochronosis can be treated symptomatically during the early stages, whereas for end stages total joint and heart valve replacements may be required.
A South African epidemic of ochronosis of the face in dark-skinned individuals," South African Medical Journal, vol.
Therefore, the diagnosis of alkaptonuria may be delayed until ochronosis has developed.
(2), (3) Furthermore, in this disease, excessive HGA is converted to a polymeric melanin-like pigment that binds to all connective tissues in a pathophysiological process called ochronosis. (4) The total number of identified AKU-causing mutations worldwide is 115, and up-to-date information can be found in the AKU mutation database.
Prolonged use of this ingredient thickens collagen fibers, resulting in ochronosis. Mercury is another toxic ingredient which inhibits the skin's production of melanin, lightening the skin area where it is applied.
Opinions differ as to why so many African men and women want whiter skin, but whatever the reason, the health implications, which include various types of cancer and ochronosis, a disease which causes hyperpigmentation, which is often irreversible, are causes for concern.
Side effects of hydroquinone use include skin irritation, dermatitis, and ochronosis, a blue-black skin discoloration.