obligate carrier


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obligate carrier

Clinical genetics The ♂ or ♀ parent of a child with an AR disorder who, by definition, is a carrier of the defective gene is question; similarly, mothers of ♂ children with an X-R condition are carriers of the defective gene. See Autosomal recessive.
References in periodicals archive ?
Enzyme activities from obligate carriers and patients.
All the obligate carriers, parents and unaffected siblings were heterozygous for the TA deletion (c.659_660delTA).
We analyzed 84 DNA samples from the National Taiwan University Hospital, including DNA from 11 patients with dystropin gene deletions previously detected by gel electrophoresis, 1 patient with a duplication detected by the multiplex PCR/DHPLC detection method and confirmed by quantitative real-time PCR (27), 23 obligate carriers and noncarriers from families with DMD patients, and 50 unaffected females from the general population.
Clinical samples included DNA from normal female controls, affected males with deletional forms of DMD/BMD, unrelated obligate carriers containing deletions in the dystropin gene, and female family members at risk for being carriers.