obestatin


Also found in: Wikipedia.

obestatin

A peptide hormone derived from a prohormone, preproghrelin—which also contains ghrelin—by post-translational processing, originating from endocrine cells in the stomach. Obestatin is encoded by GHRL on chromosome 3p26-p25. The ratio of obestatin and ghrelin is altered in obesity and in anorexia nervosa. Initially reported as an anorexigenic hormone, recent data suggest that obestatin inhibits thirst and anxiety, improves memory, regulates sleep, affects cell proliferation, and increases secretion of the exocrine pancreas. Antisense transcripts for GHRL have been identified which regulate ghrelin-obestatin preproprotein expression.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Osteoporoz grubundaki hastalarin tedavi oncesinde, sonrasinda ve kontrol grubunda serum acil ghrelin, deacil ghrelin ve obestatin duzeyleri (ort [+ or -] SD) Osteoporoz TO (n=36) TS (n=28) Acil ghrelin 36,98 [+ or -] 8,82 39,16 [+ or -] 7,95 serum (pg/mL) Deacil ghrelin 81,30 [+ or -] 17,02 83,33 [+ or -] 13,76 serum (pg/mL) Obestatin 0,95 [+ or -] 2,13 1,64 [+ or -] 2,37 serum (ng/mL) Kontrol (n=21) p (TO-TS) Acil ghrelin 34,42 [+ or -] 12,10 AD serum (pg/mL) Deacil ghrelin 74,33 [+ or -] 22,41 AD serum (pg/mL) Obestatin 0,53 [+ or -] 1,08 AD serum (ng/mL) p (TO- p (TS- kontrol) kontrol) Acil ghrelin AD AD serum (pg/mL) Deacil ghrelin AD AD serum (pg/mL) Obestatin AD <0,05 serum (ng/mL) AD: anlamli degil; TO: tedavi oncesi; TS: tedavi sonrasi Tablo 4.
Settanni et al., "Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats," Journal of Molecular Endocrinology, vol.
The objective of the present study was to examine the effect of different doses of obestatin on testosterone secretion in pubertal male Sprague Dawley rats.
In addition, other factors such as glucagon, glucocorticoids, leptin [33], ghrelin, or obestatin [34] that could influence thermogenesis may also be modulated by thyroid hormone.
The present study was designed to investigate the in vivo effect of an anorexigenic gut peptide obestatin on plasma testosterone and prolactin secretion, in adult male Sprauge Dawley rats.
Appel, "Characteristics associated with fasting appetite hormones (obestatin, Ghrelin, and Leptin)," Obesity, vol.
Obestatin is a peptide hormone, which is released by the parietal cells in gastrointestinal tract.
Influence of short- and long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats.
The relationship between weight loss and biochemical parameters such as leptin, ghrelin, nesfatin 1, obestatin in obese individuals.
Several genes (potein kinase, CGMP-dependent, type I [PRKG1], rap guanine nucleotide exchange factor 2 [RAPGEF2], RAB17, member RAS oncogene family [RAB17], neural EGFL like 1 [NELL1], DCC netrin 1 receptor [DCC], NCK adaptor protein 2 [NCK2], ghrelin and obestatin prepropeptide [GHRL], adhesion G protein-coupled receptor B3 [ADGRB3], and NTRK2) were identified that trigger dendrite development [29-31].
Ghrelin and obestatin: Different role in fetal lung development?