obestatin


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obestatin

A peptide hormone derived from a prohormone, preproghrelin—which also contains ghrelin—by post-translational processing, originating from endocrine cells in the stomach. Obestatin is encoded by GHRL on chromosome 3p26-p25. The ratio of obestatin and ghrelin is altered in obesity and in anorexia nervosa. Initially reported as an anorexigenic hormone, recent data suggest that obestatin inhibits thirst and anxiety, improves memory, regulates sleep, affects cell proliferation, and increases secretion of the exocrine pancreas. Antisense transcripts for GHRL have been identified which regulate ghrelin-obestatin preproprotein expression.
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References in periodicals archive ?
Osteoporoz grubundaki hastalarin tedavi oncesinde, sonrasinda ve kontrol grubunda serum acil ghrelin, deacil ghrelin ve obestatin duzeyleri (ort [+ or -] SD) Osteoporoz TO (n=36) TS (n=28) Acil ghrelin 36,98 [+ or -] 8,82 39,16 [+ or -] 7,95 serum (pg/mL) Deacil ghrelin 81,30 [+ or -] 17,02 83,33 [+ or -] 13,76 serum (pg/mL) Obestatin 0,95 [+ or -] 2,13 1,64 [+ or -] 2,37 serum (ng/mL) Kontrol (n=21) p (TO-TS) Acil ghrelin 34,42 [+ or -] 12,10 AD serum (pg/mL) Deacil ghrelin 74,33 [+ or -] 22,41 AD serum (pg/mL) Obestatin 0,53 [+ or -] 1,08 AD serum (ng/mL) p (TO- p (TS- kontrol) kontrol) Acil ghrelin AD AD serum (pg/mL) Deacil ghrelin AD AD serum (pg/mL) Obestatin AD <0,05 serum (ng/mL) AD: anlamli degil; TO: tedavi oncesi; TS: tedavi sonrasi Tablo 4.
Ghrelin and obestatin levels in serum and saliva of patients with osteoporosis and the effect of strontium ranelate/Osteoporozlu hastalarin serum ve tukuruklerinde ghrelin ve obestatin duzeyleri ve stronsiyum ranelatin etkisi
Settanni et al., "Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats," Journal of Molecular Endocrinology, vol.
Ghrelin protects against dexamethasone-induced INS-1 cell apoptosis via ERK and p38MAPK signaling
The objective of the present study was to examine the effect of different doses of obestatin on testosterone secretion in pubertal male Sprague Dawley rats.
Possible Modulation of Testosterone Secretion by Obestatin in Pubertal Male Rats
In addition, other factors such as glucagon, glucocorticoids, leptin [33], ghrelin, or obestatin [34] that could influence thermogenesis may also be modulated by thyroid hormone.
Thermogenic effect of glucose in hypothyroid subjects
The present study was designed to investigate the in vivo effect of an anorexigenic gut peptide obestatin on plasma testosterone and prolactin secretion, in adult male Sprauge Dawley rats.
Obestatin Induces Testosterone But Not Prolactin Secretion in Male Sprague Dawley Rats
Appel, "Characteristics associated with fasting appetite hormones (obestatin, Ghrelin, and Leptin)," Obesity, vol.
Appetite response among those susceptible or resistant to obesity
Obestatin is a peptide hormone, which is released by the parietal cells in gastrointestinal tract.
EFFECT OF OBESTATIN SUPPLEMENTATION ON PLASMA GLUCOSE, SERUM INSULIN AND INSULIN RESISTANCE IN HIGH FAT DIET INDUCED OBESE SPRAGUE DAWLEY RATS
Effect of Helicobacter pylori eradication on serum ghrelin and obestatin levels.
Standard triple therapy in Helicobacter pylori eradication in Turkey: Systematic evaluation and meta-analysis of 10-year studies
Influence of short- and long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats.
Alteraciones en la Morfologia y Resistencia Aerobica de Animales Sometidos a Diferentes Protocolos de Entrenamiento
The relationship between weight loss and biochemical parameters such as leptin, ghrelin, nesfatin 1, obestatin in obese individuals.
Serum Concentration of Ghrelin, Oxidative Stress and Lipid Parameters in Obese Subjects
Several genes (potein kinase, CGMP-dependent, type I [PRKG1], rap guanine nucleotide exchange factor 2 [RAPGEF2], RAB17, member RAS oncogene family [RAB17], neural EGFL like 1 [NELL1], DCC netrin 1 receptor [DCC], NCK adaptor protein 2 [NCK2], ghrelin and obestatin prepropeptide [GHRL], adhesion G protein-coupled receptor B3 [ADGRB3], and NTRK2) were identified that trigger dendrite development [29-31].
Analysis of cross-population differentiation between Thoroughbred and Jeju horses
Ghrelin and obestatin: Different role in fetal lung development?
Distribution and Morphology of Ghrelin-Immunopositive Cells in the Lung of the African Ostrich
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