obesogen


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obesogen

An exogenous substance that alters lipid homeostasis and fat storage, changes metabolic setpoints, disrupts energy balance or modifies the regulation of appetite and satiety, promoting fat accumulation and obesity.

Mechanisms of action
Alteration of metabolic sensing, neuroendocrine effects, cell signalling, dysregulation of steroid hormones.

Obesogens
Pharmaceutical obesogens
• Metabolic sensors—Act on PPAR-gamma receptor (e.g., thiazolidinediones, rosiglitazone);
• Sex steroid dysregulation—DES caused obesity in adults;
• Central—Act on neurotransmitter receptors (e.g., SSRIs, antidepressants).

Environmental obesogens
• Organotin;
• Xernobiotics.
References in periodicals archive ?
Since BPS is a substitute for BPA, which is suspected to be an obesogen, the link between BPS and obesity that we found is of interest.
Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach
Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes.
Estimated daily intake and cumulative risk assessment of phthalates in Taiwan military personnel
They've also found some other chemicals used in plastics that are used to make things like toys that are called dibenzoates, that are likely to be a obesogen as well.
Emerging Risks: An industry expert explains why plastics may be the next product sending the industry into litigation
Endocrine aspects of environmental "obesogen" pollutants.
The influence of bisphenol a in the development of obesity/ A INFLUENCIA DO BISFENOL A NO DESENVOLVIMENTO DA OBESIDADE
Based on the findings of the review, the researchers suggest specific recommendations to reduce obesogen exposure.
Reducing exposure to hormone-disrupting chemicals to tackle obesity
Gregory et al., "Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice," The Journal of Nutritional Biochemistry, vol.
Contribution of Inhibitor of DNA Binding/Differentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease
Dirtu et al., "Expression of obesity markers and persistent organic pollutants levels in adipose tissue of obese patients: reinforcing the obesogen hypothesis?" PLoS ONE, vol.
The changes of serum leptin and kisspeptin levels in Chinese children and adolescents in different pubertal stages
Triflumazole is an obesogen in mice that acts through peroxisome proliferator activated receptor gamma (PPAR[gamma]).
Worker illness related to newly marketed pesticides--Douglas County, Washington, 2014
The environmental obesogen hypothesis suggests that prenatal or early-life exposure to certain substances as EDCs may predispose exposed individuals to increased fat mass and excess weight.
Role of environmental chemicals in obesity: a systematic review on the current evidence
This result is interesting because iAs is not thought to be an obesogen. In fact, we have previously reported that C57BL/6 mice fed a HFD and exposed to much higher levels of iAs in drinking water (25 and 50 ppm) had less %fat than control unexposed mice (Paul et al.
Metabolic Phenotype of Wild-Type and As3mt-Knockout C57BL/6J Mice Exposed to Inorganic Arsenic: The Role of Dietary Fat and Folate Intake
"Our study suggests that BPA could be a potential new environmental obesogen, a chemical compound that can disrupt the normal development and balance of lipid metabolism, which can lead to obesity," Dr.
Chemical in plastics may double obesity risk in puberty-age girls
Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice.
Effects of the Endocrine-Disrupting Chemicals, Vinclozolin and Polychlorinated Biphenyls, on Physiological and Sociosexual Phenotypes in F2 Generation Sprague-Dawley Rats
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