obesogen


Also found in: Wikipedia.

obesogen

An exogenous substance that alters lipid homeostasis and fat storage, changes metabolic setpoints, disrupts energy balance or modifies the regulation of appetite and satiety, promoting fat accumulation and obesity.

Mechanisms of action
Alteration of metabolic sensing, neuroendocrine effects, cell signalling, dysregulation of steroid hormones.

Obesogens
Pharmaceutical obesogens
• Metabolic sensors—Act on PPAR-gamma receptor (e.g., thiazolidinediones, rosiglitazone);
• Sex steroid dysregulation—DES caused obesity in adults;
• Central—Act on neurotransmitter receptors (e.g., SSRIs, antidepressants).

Environmental obesogens
• Organotin;
• Xernobiotics.
References in periodicals archive ?
Since BPS is a substitute for BPA, which is suspected to be an obesogen, the link between BPS and obesity that we found is of interest.
Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes.
They've also found some other chemicals used in plastics that are used to make things like toys that are called dibenzoates, that are likely to be a obesogen as well.
Based on the findings of the review, the researchers suggest specific recommendations to reduce obesogen exposure.
Gregory et al., "Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice," The Journal of Nutritional Biochemistry, vol.
Dirtu et al., "Expression of obesity markers and persistent organic pollutants levels in adipose tissue of obese patients: reinforcing the obesogen hypothesis?" PLoS ONE, vol.
Triflumazole is an obesogen in mice that acts through peroxisome proliferator activated receptor gamma (PPAR[gamma]).
The environmental obesogen hypothesis suggests that prenatal or early-life exposure to certain substances as EDCs may predispose exposed individuals to increased fat mass and excess weight.
This result is interesting because iAs is not thought to be an obesogen. In fact, we have previously reported that C57BL/6 mice fed a HFD and exposed to much higher levels of iAs in drinking water (25 and 50 ppm) had less %fat than control unexposed mice (Paul et al.
"Our study suggests that BPA could be a potential new environmental obesogen, a chemical compound that can disrupt the normal development and balance of lipid metabolism, which can lead to obesity," Dr.