LEP(redirected from obese, mouse, homolog of)
Also found in: Dictionary, Encyclopedia.
LEPA gene on chromosome 7q31.3 that encodes leptin, a protein secreted by white adipocytes, which plays a key role in regulating body weight. By binding to its cognate receptor, leptin is part of a signalling pathway which inhibits food intake and regulates energy expenditure to maintain fat homeostasis. Leptin plays a role in the endocrine system, and is involved in regulating immune and inflammatory responses, haematopoiesis, angiogenesis, reproduction, glucose homeostasis, bone formation, and wound healing.
Mutations of LEP and/or its regulatory regions are linked to obesity, morbid obesity with hypogonadism, and type-2 diabetes.
low egg passage, with reference to virus attenuation usually for vaccine production.