ob gene

A gene on chromosome 7 that codes for the cytokine LEPTIN which is produced in adipose tissue and which exercises control over food intake and energy expenditure. Ob is an abbreviation of ‘obesity’.

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References in periodicals archive ?

Interestingly, leptin has been shown to play a significant role in the pathophysiology of insulin resistance related to obesity because leptin replacement reverses insulin resistance and diabetes in mice homozygous for mutations of the ob gene.

Relationship between leptin and indices of obesity among apparently healthy adults in Kano, Northwestern Nigeria

Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes.

Dexamethasone and acetate modulate cytoplasmic leptin in Bovine preadipocytes

Novel polymorphism of the human ob gene promoter in lean and morbidly obese subjects.

A G15719C leptin gene polymorphism is associated with lesser perception of stress and other physiological reactions to stress in adult working Pakistani women

Evidence against either a premature stop codon or the absence of Ob gene mRNA in human obesity.

Increased serum leptin indicates leptin resistance in obesity

Moses AG, Dowder N, Hollway B, Waddell I, Fearon KC, Ross JA: Leptin and its relation to weight loss, ob gene expression acute-phase response in surgical patients.

Leptin levels in patients with Behcet's disease/Behcet hastalarinda leptin duzeyleri

Leptin, the product of the ob gene, is believed to be involved in regulating neuroendocrine (both hypothalamic and gonadal) mechanisms of reproduction.

Leptin evaluation and cytogenetic profiles to elucidate factors affecting reproductive performance of the creme d'Argent - an endangered rabbit breed

Animals with mutations in the ob gene are obese and lose weight when given leptin, but little is known about the physiologic actions of leptin in humans.

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

The protein product of the ob gene, called leptin, mainly but not exclusively produced by white adipose tissue, is thought to suppress appetite and regulate energy homeostasis (1,2).

Can maternal leptin level at early gestation be used as a predictor of postpartum weight retention?

Leptin, the product of Ob gene promotes angiogenesis.

Perfil fisiologico de la leptina

C57BL/KsJ is an inbred strain distinct from the CS7BL/6J strain, which serves as the recipient of the ob gene.

Ginseng berry reduces blood glucose and body weight in db/db mice

Mutation of the mouse ob gene results in profound obesity and Type 11 diabetes as part of a syndrome that resembles morbid obesity (body weight exceeding 100% of ideal) in humans (Friedman, Leibel, Siegel, Walsh, & Bahary, 1991).