ob gene

A gene on chromosome 7 that codes for the cytokine LEPTIN which is produced in adipose tissue and which exercises control over food intake and energy expenditure. Ob is an abbreviation of ‘obesity’.

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leptin

References in periodicals archive ?

Interestingly, leptin has been shown to play a significant role in the pathophysiology of insulin resistance related to obesity because leptin replacement reverses insulin resistance and diabetes in mice homozygous for mutations of the ob gene. [11]

Relationship between leptin and indices of obesity among apparently healthy adults in Kano, Northwestern Nigeria

Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes.

Dexamethasone and acetate modulate cytoplasmic leptin in Bovine preadipocytes

Novel polymorphism of the human ob gene promoter in lean and morbidly obese subjects.

A G15719C leptin gene polymorphism is associated with lesser perception of stress and other physiological reactions to stress in adult working Pakistani women

Evidence against either a premature stop codon or the absence of Ob gene mRNA in human obesity.

Increased serum leptin indicates leptin resistance in obesity

Leptin, the product of the ob gene, is believed to be involved in regulating neuroendocrine (both hypothalamic and gonadal) mechanisms of reproduction.

Leptin evaluation and cytogenetic profiles to elucidate factors affecting reproductive performance of the creme d'Argent - an endangered rabbit breed

Leptin, the product of the ob gene, is a hormone secreted by adipocytes.

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

The protein product of the ob gene, called leptin, mainly but not exclusively produced by white adipose tissue, is thought to suppress appetite and regulate energy homeostasis (1,2).

Can maternal leptin level at early gestation be used as a predictor of postpartum weight retention?

Leptin, the product of Ob gene promotes angiogenesis.

Perfil fisiologico de la leptina

C57BL/KsJ is an inbred strain distinct from the CS7BL/6J strain, which serves as the recipient of the ob gene. In the C57BL/KsJ strain of mice, the diabetes db gene mutation occurred spontaneously (Shafrir, 1992).

Ginseng berry reduces blood glucose and body weight in db/db mice

Mutation of the mouse ob gene results in profound obesity and Type 11 diabetes as part of a syndrome that resembles morbid obesity (body weight exceeding 100% of ideal) in humans (Friedman, Leibel, Siegel, Walsh, & Bahary, 1991).

Obesity: genetic update and clinical implications

When these changes near the OB gene occur in combination with a version of the D2 dopamine receptor gene known as the A1 allele, the likelihood of obesity in young women rises even further, they argue.