ob gene

ob gene

A gene on chromosome 7 that codes for the cytokine LEPTIN which is produced in adipose tissue and which exercises control over food intake and energy expenditure. Ob is an abbreviation of ‘obesity’.
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Interestingly, leptin has been shown to play a significant role in the pathophysiology of insulin resistance related to obesity because leptin replacement reverses insulin resistance and diabetes in mice homozygous for mutations of the ob gene.
Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes.
Evidence against either a premature stop codon or the absence of Ob gene mRNA in human obesity.
Moses AG, Dowder N, Hollway B, Waddell I, Fearon KC, Ross JA: Leptin and its relation to weight loss, ob gene expression acute-phase response in surgical patients.
Leptin, the product of the ob gene, is believed to be involved in regulating neuroendocrine (both hypothalamic and gonadal) mechanisms of reproduction.
Animals with mutations in the ob gene are obese and lose weight when given leptin, but little is known about the physiologic actions of leptin in humans.
The protein product of the ob gene, called leptin, mainly but not exclusively produced by white adipose tissue, is thought to suppress appetite and regulate energy homeostasis (1,2).
Leptin, the product of Ob gene promotes angiogenesis.
C57BL/KsJ is an inbred strain distinct from the CS7BL/6J strain, which serves as the recipient of the ob gene.
Mutation of the mouse ob gene results in profound obesity and Type 11 diabetes as part of a syndrome that resembles morbid obesity (body weight exceeding 100% of ideal) in humans (Friedman, Leibel, Siegel, Walsh, & Bahary, 1991).
Every time we turn around there's another major finding - the OB gene (which controls obesity), leptin, brain peptides.