ob gene

ob gene

A gene on chromosome 7 that codes for the cytokine LEPTIN which is produced in adipose tissue and which exercises control over food intake and energy expenditure. Ob is an abbreviation of ‘obesity’.
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Interestingly, leptin has been shown to play a significant role in the pathophysiology of insulin resistance related to obesity because leptin replacement reverses insulin resistance and diabetes in mice homozygous for mutations of the ob gene. [11]
Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes.
Evidence against either a premature stop codon or the absence of Ob gene mRNA in human obesity.
Leptin, the product of the ob gene, is believed to be involved in regulating neuroendocrine (both hypothalamic and gonadal) mechanisms of reproduction.
Leptin, the product of the ob gene, is a hormone secreted by adipocytes.
The protein product of the ob gene, called leptin, mainly but not exclusively produced by white adipose tissue, is thought to suppress appetite and regulate energy homeostasis (1,2).
Leptin, the product of Ob gene promotes angiogenesis.
C57BL/KsJ is an inbred strain distinct from the CS7BL/6J strain, which serves as the recipient of the ob gene. In the C57BL/KsJ strain of mice, the diabetes db gene mutation occurred spontaneously (Shafrir, 1992).
Mutation of the mouse ob gene results in profound obesity and Type 11 diabetes as part of a syndrome that resembles morbid obesity (body weight exceeding 100% of ideal) in humans (Friedman, Leibel, Siegel, Walsh, & Bahary, 1991).
When these changes near the OB gene occur in combination with a version of the D2 dopamine receptor gene known as the A1 allele, the likelihood of obesity in young women rises even further, they argue.