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a cytotoxic compound that causes severe damage to the adrenal cortex; administered orally as an antineoplastic agent for palliative treatment of inoperable adrenocortical carcinoma.


Lysodren® Oncology A cytotoxic agent that controls the endocrine Sx in Pts with adrenocortical CA and ACTH producing pituitary tumors that cause Cushing's disease Adverse effects Anorexia, N&V, neurologic disturbances–ataxia, speech defects, somnolence, vertigo, lethargy, liver enzyme changes–↑ ALA, ALT, alkaline phosphatase, GGT, ↑ corticosteroid-binding globulin, ↑ sex hormone-binding globulin, ↑ cholesterol, ↓ uric acid, ↓ thyroid hormones–normal TSH. See Adrenocortical carcinoma.

Patient discussion about mitotane

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References in periodicals archive ?
According to the IUPAC, limits of detection (LD) were designated as three-fold the SD of the blank, and were the following: 0.05 ng/mL for [alpha]-HCH; 0.07 ng/mL for [beta]-HCH, HCB, heptachlor epoxide A, and endosulfan I; 0.04 ng/mL for [gamma]-HCH; 0.13 ng/mL for o,p'-DDT; 0.02 ng/mL for p,p'-DDT; 0.12 ng/mL for p,p'-DDD and o,p'-DDD; 0.09 ng/mL for heptachlor epoxide B, trans-nonachlor, [alpha]-chlordane, [gamma]-chlordane, dieldrin, and p,p'-DDE; 0.29 ng/mL for endrin; 0.14 ng/mL for methoxychlor; 0.10 ng/mL for o,p'-DDE, aldrin, and mirex; 0.11 ng/mL for endosulfan II; and 0.06 ng/mL for pentachloroanisole.
We excluded studies to assess the therapeutic use of o,p'-DDD iso-form, commercially known as mitotane or lysodren.
Among the analysed pesticide residues, the following residues were detected in cabbage: p,p'-DDT, p,p'-DDD, o,p'-DDD, endosulfans, chlorpyrifos, and cypermethrin.
In this method, 1 L of continental water, spiked with 5 [micro]L of anthracene deuterated (10 ng [micro][L.sup.-1]) as surrogate, is employed to determine the selected organochlorine pesticides (p,p'-DDD, o,p'-DDD, p,p'-DDE, o,p'-DDE, p,p'-DDT, o,p'-DDT, [ALPHA]-HCH, [beta]-HCH, [gamma]-HCH, atrazine, simazine, metolachlor, terbuthylazine, aldrin, dieldrin, endrin, isodrin, and hexachlorobenzene).
En los sedimentos del area de Macuspana se presentaron o,p'-DDD y el o,p'-DDE, en todas las estaciones recolectadas.
The following analytes were not detected above the MDL in any squirrel liver samples: [alpha]-HCH, [beta]-HCH, [delta]-HCH, heptachlor, aldrin, endosulfan 2, pentachloroanisole, and o,p'-DDE, o,p'-DDD, o,p'-DDT and PCBs 29, 44, and 200.
The concentrations of the other DDT congeners, p,p'-DDT, p,p'-DDD, 41-DDT, and o,p'-DDD, were not detectable in either tissue at either age (data not shown).
The median (interquartile range) concentrations for the respective DDT isomers (micrograms per gram lipid) in cases were as follows: o,p'-DDT, 0.37 (0.00-1.25); p,p'-DDT, 5.66 (1.54-22.40); o,p'-DDD [1,1-dichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl) ethane], 0.00 (0.00-0.28); p,p'-DDD, 0.00 (0.00-0.50); o,p'-DDE, 0.00 (0.00-0.17); p,p'-DDE, 34.12 (0.71-120.78).
For the remaining eight compounds [methoxychlor, cis-chlordane, PCA, [gamma]-HCH, 1,1-dichloro-2-(2-chlorophenyl)-2,2(4-chlorophenyl)ethane (o,p'-DDD), trans-chlordane, [alpha]-HCH, 1,1-dichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl) ethylene (o,p'-DDE)], the total detection rate varied between 26.9 and 71.5%.
However, o,p'-DDE, o,p'-DDD, aldrin, endrin, and methoxychlor were not detected in any of the tissues in this study.
For DDT-related compounds, only p,p'-DDT and p,p'-DDE were retained in the analysis because these compounds comprised 19% and 80%, respectively, of the total geometric mean lipid-adjusted concentration for the six DDT-related compounds (p,p'-DDD, o,p'-DDD, p,p'-DDE, o,p'-DDE, p,p'-DDT, o,p'-DDT).
1997: hER reporter in yeast/ Miller units [beta]- galactosidase enzyme activity Estradiol-17[beta] (reference chemical) 1 0.4360 o,p'-DDT 50 0.3960 o,p'-DDT 1,000 0.6550 o,p'-DDE 1,000 0.6750 o,p'-DDD 1,000 0.5810 p,p'-DDT 1,000 0.4950 p,p'-DDE 1,000 0.0000 p,p'-DDA 1,000 0.0000 Chen et al.