null cell


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null cell

A large lymphocyte without the cell markers of either a T cell or a B cell. Natural killer cells are examples of null cells.
See also: cell
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Null cell adenoma--a separate category not clearly reflected in the developmental biology of the anterior pituitary--was defined by Kovacs et al (24) as pituitary adenoma unassociated clinically or biochemically with increased hormone secretion and containing no adenohypophyseal hormones by immunohistochemistry and by electron microscopy; null cell adenoma accounted for approximately 16% of their series of 343 surgically removed adenomas.
Falini et al in his study showed that ALCL ALK positive cases were mostly present in present study 92% cases were CD 3 positive and rest of cases were CD 45RO positive with no case of null cell phenotype.
A band corresponding to ~1117 bp is seen (Figure 3, panel A, lane 3) when RNA extracted from null cells of Dictyostelium was reverse transcribed and subjected to PCR amplification.
In general, gonadotroph or null cell adenomas tend to have scant cytoplasm and bland nuclear cytologic features (Figure 1, b).