nude mouse


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mouse

 [mows]
a small rodent, various species of which are used in laboratory experiments.
1. a small loose body.
2. a computer pointing device.
joint mouse a movable fragment of synovial membrane, cartilage, or other body within a joint; usually associated with degenerative osteoarthritis and osteochondritis dissecans.
knockout mouse a mouse that has had a specific gene artificially deleted from its genome.
nude mouse a mouse homozygous for the nu gene; these mice are hairless, lack a thymus, and thus lack T lymphocytes.
peritoneal mouse a free body in the peritoneal cavity, probably a small detached mass or omentum, sometimes visible radiographically.
SCID mouse (severe combined immunodeficiency) a strain of mice lacking in T and B lymphocytes and immunoglobulins, either from inbreeding with an autosomal recessive trait or from genetic engineering, used as a model for studies of the immune system.

nude mouse

a hairless mutant mouse with thymic hypoplasia, lacking T cells.
A mutant strain of lab mouse that is hairless, thymusless due to congenital thymic aplasia, and T cell-less.

nude mouse

inbred strain of laboratory mouse which is hairless and has no thymic tissue. Because it has no source of T lymphocytes, it suffers from a defect in cell-mediated immunity and is highly susceptible to infections. This trait is utilized for immunological studies. Called also athymic mouse.
References in periodicals archive ?
In conclusion, this preliminary study examined the viability, host response, and volume retention characteristics of drilled human cartilage slurry injected into a nude mouse model over a 6-month period.
Overstrom's laboratories will lead to both significant benefits to researchers who use research models such as the nude mouse, and also lead to improved efficiency of production of models at Charles River.
ISIS 2503 has been demonstrated to inhibit the growth of several different human cancers in nude mouse xenograft models, including lung, breast, colon and bladder tumors.
In both flank and systemic nude mouse models, the combination regimen of ONCONASE and doxorubicin had a significantly greater effect than either drug alone demonstrating a synergism of this drug combination against human MDA-MB-231 breast cancer.
LXR will conduct toxicity studies with human Maspin and will also conduct tumor inhibition studies with human Maspin in the nude mouse model.
It inhibits tumor growth in the nude mouse xenograft model with two primary human squamous cell tumors.