nucleus pulposus

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 [noo´kle-us] (pl. nu´clei) (L.)
1. cell nucleus; a spheroid body within a cell, contained in a double membrane, the nuclear envelope, and containing the chromosomes and one or more nucleoli. The contents are collectively referred to as nucleoplasm. The chromosomes contain deoxyribonucleic acid (DNA), which is the genetic material that codes for the structure of all the proteins of the cell.
2. a mass of gray matter in the central nervous system, especially such a mass marking the central termination of a cranial nerve.
3. in organic chemistry, the combination of atoms forming the central element or basic framework of the molecule of a specific compound or class of compounds.
4. the dense core of an atom, made of protons and neutrons held together by the strong nuclear force. Traveling in orbit around it is a cloud of negatively charged particles called electrons. The number of protons in the atomic nucleus gives a substance its identity as a particular element. Called also atomic nucleus. adj., adj nu´clear.
The nucleus and nucleolus of a cell. From Mahon and Manuselis, 2000.
nucleus ambi´guus the nucleus of origin of motor fibers of the glossopharyngeal, vagus, and accessory nerves in the medulla oblongata.
nucleus an´sae lenticula´ris (nucleus of ansa lenticularis) a collection of neurons in the ansa lenticularis as it curves around the medial edge of the globus pallidus.
arcuate nuclei of medulla oblongata, nu´clei arcua´ti medul´lae oblonga´tae small irregular areas of gray substance on the ventromedial aspect of the pyramid of the medulla oblongata.
atomic nucleus nucleus (def. 3).
basal nuclei (nu´clei basa´les) specific interconnected subcortical masses of gray matter embedded in each cerebral hemisphere and in the upper brainstem, comprising the corpus striatum (caudate and lentiform nuclei), amygdaloid body, claustrum, and external, extreme, and internal capsules. Called also basal ganglia.
caudal olivary nucleus a folded band of gray substance enclosing a white core, which produces the elevation on the medulla oblongata known as the olive.
caudate nucleus (nucleus cauda´tus) an elongated, arched gray mass closely related to the lateral ventricle throughout its entire extent, which, together with the putamen, forms the neostriatum.
nucleus ceru´leus a compact aggregation of pigmented neurons lying below the locus ceruleus.
cochlear nuclei, anterior and posterior the nuclei of termination of sensory fibers of the cochlear nerve (see anatomic Table of Nerves in the Appendices); they partly encircle the inferior cerebellar peduncle at the junction of the medulla oblongata and pons.
dentate nucleus (nucleus denta´tus) the largest of the deep cerebellar nuclei, lying in the white matter of the cerebellum just lateral to the emboliform nucleus.
droplet nuclei small particles of pathogen-containing respiratory secretions expelled into the air by coughing, which are reduced by evaporation to small, dry particles that can remain airborne for long periods; one possible mechanism for transmission of infection from one individual to another.
emboliform nucleus (nucleus embolifor´mis) a small cerebellar nucleus lying between the dentate nucleus and the globose nucleus and contributing to the superior cerebellar peduncles.
fastigial nucleus (nucleus fasti´gii) the most medial of the deep cerebellar nuclei, near the midline in the roof of the fourth ventricle.
globose nucleus (nucleus globo´sus) a cerebellar nucleus lying between the emboliform nucleus and the nucleus fastigii and projecting its fibers via the superior cerebellar peduncle.
intracerebellar nuclei four accumulations of gray matter embedded in the white matter of the cerebellum, comprising the dentate nucleus, emboliform nucleus, nucleus fastigii, and globose nucleus.
lenticular nucleus (lentiform nucleus) the part of the corpus striatum somewhat resembling a biconvex lens, divided into a larger external or lateral part called the putamen and a smaller light colored internal or medial part called the globus pallidus.
motor nucleus any collection of cells in the central nervous system giving origin to a motor nerve.
olivary nucleus a folded band of gray matter that encloses a white core and produces the elevation called the olive on the medulla oblongata; it receives heavy projections from the spinal cord, mesencephalon, and cerebral cortex and projects fibers via the contralateral inferior cerebellar peduncle.
nuclei of origin, nu´clei ori´ginis groups of nerve cells in the central nervous system from which arise the motor, or efferent, fibers of the cranial nerves.
paraventricular nucleus (nucleus paraventricula´ris) a band of cells in the wall of the third ventricle in the supraoptic part of the hypothalamus; many of its cells are neurosecretory in function and project to the neurohypophysis, where they secrete oxytocin (and, to a lesser extent, antidiuretic hormone).
pontine nuclei, nu´clei pon´tis masses of nerve cells scattered throughout the ventral part of the pons, in which the longitudinal fibers of the pons terminate, and whose axons in turn cross to the opposite side and form the middle cerebellar peduncle, which projects fibers to the neocerebellum.
nucleus pro´prius a column of large neurons that extends throughout the posterior horn of the spinal cord.
nucleus pulpo´sus (pulpy nucleus) a semifluid mass of fine white elastic fibers forming the center of an intervertebral disk.
red nucleus (nucleus ru´ber) an oval mass of gray matter (pink in fresh specimens) in the anterior part of the tegmentum and extending into the posterior part of the hypothalamus; it receives fibers from the cerebellum.
sensory nucleus the nucleus of termination of the afferent (sensory) fibers of a peripheral nerve.
supraoptic nucleus (nucleus supraop´ticus) one just above the lateral part of the optic chiasm; many of its cells are neurosecretory in function and project to the neurohypophysis, where they secrete antidiuretic hormone (ADH) and, to a lesser extent, oxytocin; other cells are osmoreceptors that stimulate ADH release in response to increased osmotic pressure.
tegmental nucleus, laterodorsal several nuclear masses of the reticular formations of the pons and midbrain, especially of the latter, where they are in close approximation to the superior cerebellar peduncles.
thoracic nucleus (nucleus thora´cicus) thoracic column.
vestibular nuclei, nu´clei vestibula´res the four cellular masses in the floor of the fourth ventricle: superior (rostral or cranial), lateral, medial, and inferior (caudal) vestibular nuclei; in them are the terminations of the branches of the vestibular nerve (see anatomic Table of Nerves in the Appendices). The nuclei give rise to a widely dispersed special sensory system through projections to motor nuclei in the brain stem and cervical cord, to the cerebellum, and to motor cells throughout the spinal cord; they also have connections that provide for conscious perception of, and autonomic reactions to, labyrinthine stimulation.

nu·cle·us pul·po·'sus

the soft fibrocartilage central portion of the intervertebral disc; regarded as a derivative of the notochord.

nucleus pulposus

the gelatinous center of a vertebral disk. See pulpy nucleus.

nucleus pulposus

The pulpy core of the INTERVERTEBRAL DISC, that is surrounded by the ANNULUS FIBROSUS. Degeneration of the annulus and/or undue vertical stress may lead to some of the nucleus pulposus being squeezed (prolapsed) through the annulus. This usually occurs at the back of the disk and the prolapsed material may press on the nerve roots entering and leaving the spinal cord, causing severe pain and sometimes muscle weakness. The imprecise lay term for this process is ‘slipped disk’.

Nucleus pulposus (NP)

The center portion of the intervertebral disk that is made up of a gelatinous substance.

nucleus pulposus

central fibrocartilaginous portion of an intervertebral disc; may herniate to form a 'slipped disc', causing pressure on local spinal nerves
References in periodicals archive ?
It consists of the nucleus pulposus and the annulus fibrosus.
2) Remnants of the notochord are found in the nucleus pulposus and in the clival bone marrow.
Outside of its normal confines, the nucleus pulposus promotes nerve root inflammation, which, in turn, stimulates cytokine release into the area of injury (Kang, Stefanovic-Racic, McIntyre, Georgescu & Evans, 1997; Takahashi et al.
HERNIATED NUCLEUS PULPOSUS of a lumbar intervertebral disk with radiculopathy is common in adults but is uncommon in children and adolescents, accounting for less than 2% of the reported cases of lumbar disk herniation.
Apart from tumors, other causes of sciatica-type pain in the absence of radiculopathy due to herniated nucleus pulposus include the following: arachnoiditis, discitis, hip disease, compartment syndrome of the posterior thigh, sciatic nerve injury from intramuscular injection or projectile, Lyme disease, herpes zoster, and piriformis syndrome (Greenberg, 2001).
On Wednesday, May 10, during the Spine Arthroplasty Society (SAS) meeting in Montreal, CryoLife is conducting an industry workshop for attendees entitled: "BioDisc NPR: An emerging technology for nucleus pulposus replacement.
The cell-based therapy uses the dermal cells to differentiate into cartilage type cells necessary to regrow the nucleus pulposus.
a biomaterials and biosurgical device company, announced today at the MedTech Insight In Spine & Orthopedics Meeting in North Dallas, Texas that BioDisc(TM) Spinal Disc Repair System, a nucleus pulposus repair device, has been successfully implanted in four patients.
Using intermittent hydrostatic pressure, the dermal cells were successfully differentiated into cartilage type cells necessary to regrow the nucleus pulposus.
The nucleus pulposus is surrounded by fibrous tissue (annulus) and is located in the center of the vertebral disc.
Stabilimax offers an intriguing alternative to spinal fusion; the opportunity to stabilize the spine without eliminating motion for patients with spinal stenosis or herniated nucleus pulposus, in particular, is an area of great interest to me.
The NeuDisc(TM) spinal nucleus implant is designed to replace the native nucleus pulposus, restore function to the disc, and slow or reverse the degenerative process.

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