nucleus basalis of Meynert


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nucleus basalis of Meynert

A nucleus with large cells in the substantia innominata. The nucleus basalis is interconnected with the amygdala, and it innervates most of the cortex of the cerebral hemisphere. Axons from this nucleus are cholinergic. The neurons in this nucleus degenerate if the brain develops Alzheimer disease.
Synonym: basal nucleus; nucleus basalis
References in periodicals archive ?
Computer graphic software was used to provide a 3-D model of the nucleus basalis of Meynert in an effort to "determine where to distribute CERE-110 in the NBM and how much should be given to achieve optimal NGF exposure.
Major finding: At 24 months, human nerve growth factor gene therapy via bilateral stereotactic injection into the nucleus basalis of Meynert was safe and well tolerated, PET imaging showed no evidence of accelerated decline, and brain autopsy tissue from three patients who died of unrelated causes confirmed long-term, therapeutically active, gene-mediated NGF expression.
Coronal sections (30 [micro]m) containing prelimbic and infralimbic cortex (PLc and ILc, respectively), nucleus accumbens core (NACc), nucleus accumbens shell (NACs), anterodorsal thalamus (ADT), anteroventral thalamus (AVT), anteromedial thalamus (AMT), nucleus basalis of Meynert (NBM), CA1, CA3, dentate gyrus (DG), medial mammillary nucleus (MM), lateral mammillary nucleus (LM) and ventral tegmental area (VTA) were studied.

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