nucleus basalis of Meynert


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nucleus basalis of Meynert

A nucleus with large cells in the substantia innominata. The nucleus basalis is interconnected with the amygdala, and it innervates most of the cortex of the cerebral hemisphere. Axons from this nucleus are cholinergic. The neurons in this nucleus degenerate if the brain develops Alzheimer disease.
Synonym: basal nucleus; nucleus basalis
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References in periodicals archive ?
Major finding: At 24 months, human nerve growth factor gene therapy via bilateral stereotactic injection into the nucleus basalis of Meynert was safe and well tolerated, PET imaging showed no evidence of accelerated decline, and brain autopsy tissue from three patients who died of unrelated causes confirmed long-term, therapeutically active, gene-mediated NGF expression.
In summary, this study reports for the first time reduced VAChT availability in both the Nucleus Basalis of Meynert and medial septum projection areas in AD brain tissues.
Thus, we explored the nucleus basalis of Meynert (Rispoli et al., 2008), the dorsal hippocampus (Cimadevilla, Lopez, Nieto, Aguirre, & Fernandez, 2009; Jung, Wiener, & McNaughton, 1994) and associated regions (medial prefrontal cortex, nucleus accumbens, anterior thalamus, mammillary bodies and ventral tegmental area), which are involved in the performance of spatial tasks in rats (Delatour & Gisquet-Verrier, 2000; Levin, Briggs, Christopher, & Auman, 1994; Romanides, Duffy, & Kalivas, 1999; Vann & Aggleton, 2003; Warburton, Baird, Morgan, Muir, & Aggleton, 2001).

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