nucleus accumbens


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nu·cle·us ac·cum·'bens

[TA]
the region of fusion between the head of the caudate nucleus and the putamen, covered on its inferior aspect by the olfactory tubercle. Its former name nucleus accumbens septi ("a nucleus leaning against the septum") refers to a medial, hook-shaped expansion of this anteroventral region of the striatum, which curves under the floor of the frontal horn of the lateral ventricle and ascends for some distance into the ventral half of the septal region. Composed of a pars lateralis [TA] (lateral part [TA] or core region [TAalt]) and a pars medialis [TA] (medial part [TA] or shell region [TAalt]).

nucleus accumbens

A limbic nucleus that sits at the ventral head of the striatum, contiguous with the caudate and putamen and adjacent to the olfactory tubercle. The nucleus accumbens is part of the ventral striatum nuclei. Synapses in the nucleus accumbens use dopamine as their neurotransmitter. Increasing the activity of these synapses (i.e., increasing the level of dopamine in the nucleus) leads to a rewarding or pleasurable sensation. This is thought to partly explain the addictive effect of those drugs, such as cocaine and amphetamine, that increase the level of dopamine in the nucleus accumbens.
See also: nucleus
References in periodicals archive ?
The researchers concluded: "Compounds that activate A2A receptors in the nucleus accumbens may open safe therapeutic avenues for treating insomnia, which is one of the most common sleep problems with an estimated prevalence of 10-15 percent in the general population and 30-60 percent in the older population.
Transient manic-like episode following bilateral deep brain stimulation of the nucleus accumbens and the internal capsule in a patient with Tourette syndrome.
Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine.
Dopamine and serotonin release in dorsal striatum and nucleus accumbens is differentially modulated by morphine in DBA/2J and C57BL/6J mice.
Previous studies have indicated that dopaminergic and serotonergic systems of the nucleus accumbens have a critical role in opioid dependence.
Alcohol-seeking behavior is associated with increased glutamate transmission in basolateral amygdala and nucleus accumbens as measured by glutamate-oxidase-coated biosensors.
In addition, an increase in the extracellular serotonin levels has been reported in the nucleus accumbens after alcohol administration (Yan, 1999).
To investigate a possible mechanism underlying the effect of limonene on locomotor activity induced by METH, the extracellular levels of dopamine in the nucleus accumbens of rats was measured.
Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens.
Morphine was injected subcutaneously on a volume of 1 ml/kg and other drugs were given intra- nucleus accumbens on a volume of 0.
Nucleus accumbens, which is involved in the neural pathways associated with reward and motivation, may also be the target of DBS due to its favourable effect on anhedonia as a key symptom of Treatment-Resistant Depression (TRD) [34].
Dopamine release and metabolism in nucleus accumbens and striatum of morphine tolerant and nontolerant rats.