nucleus accumbens


Also found in: Dictionary, Thesaurus, Legal, Acronyms, Encyclopedia, Wikipedia.

nu·cle·us ac·cum·'bens

[TA]
the region of fusion between the head of the caudate nucleus and the putamen, covered on its inferior aspect by the olfactory tubercle. Its former name nucleus accumbens septi ("a nucleus leaning against the septum") refers to a medial, hook-shaped expansion of this anteroventral region of the striatum, which curves under the floor of the frontal horn of the lateral ventricle and ascends for some distance into the ventral half of the septal region. Composed of a pars lateralis [TA] (lateral part [TA] or core region [TAalt]) and a pars medialis [TA] (medial part [TA] or shell region [TAalt]).

nucleus accumbens

A limbic nucleus that sits at the ventral head of the striatum, contiguous with the caudate and putamen and adjacent to the olfactory tubercle. The nucleus accumbens is part of the ventral striatum nuclei. Synapses in the nucleus accumbens use dopamine as their neurotransmitter. Increasing the activity of these synapses (i.e., increasing the level of dopamine in the nucleus) leads to a rewarding or pleasurable sensation. This is thought to partly explain the addictive effect of those drugs, such as cocaine and amphetamine, that increase the level of dopamine in the nucleus accumbens.
See also: nucleus
References in periodicals archive ?
In a general summary, it appears that stimulation and inhibition of GABA-G receptors in nucleus accumbens play an important role in expression of conditioned place preference resulting from morphine in morphine-tolerant rats.
Opiates also produce a strong increase in DA release in the nucleus accumbens (Self 2004, 242).
Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens.
The minute keyboard gradient found in the rats may translate into a slightly larger, centimeter-by-centimeter keyboard in humans' nucleus accumbens.
Two weeks after cessation of ATR exposure, rats were sacrificed by decapitation, brains were removed, and hypothalamus, prefrontal cortex, nucleus accumbens, and striatum were dissected on ice and frozen for HPLC analysis.
When the experimenter administered a single stimulation, dopamine release was evident in the caudate-putamen and nucleus accumbens core and shell.
In our laboratory, impedance patterns and frequencies of the nucleus accumbens have been similar to those of the lateral hypothalamus.
A second preclinical study evaluated the efficacy of ALKS 33 on attenuating cocaine- and amphetamine-induced elevations of dopamine in the nucleus accumbens, a key region in the brain's reward pathway, and showed that both oral and subcutaneous administration of ALKS 33 were effective.
In adrenalectomized experimental animals, the body's stress response via the HPA axis contributes to glucocorticoids and dopamine suppression in the nucleus accumbens.
Researchers examined the nucleus accumbens and the amygdala regions in the brain involved in emotional processing, motivation and reward.
However, the results suggest that one of the better target locations for DBS in patients with treatment-resistant depression (TRD) is in the nucleus accumbens, Dr.
Specifically, activation of the dopamine system within the shell region of the nucleus accumbens appears to play a key role in brain reward mechanisms (McBride et al.