nucleotide reverse transcriptase inhibitors

nucleotide reverse transcriptase inhibitors

Drugs used to treat HIV infections in combination with other antiviral medication. An example is tenofovir disoproxil (Viread).
References in periodicals archive ?
There are six main types of antiretroviral drugs that currently exist based on the stage in the viral life cycle where they are targeted: (i) nucleoside reverse transcriptase inhibitors (NRTIs) and nucleotide reverse transcriptase inhibitors (NtRTIs), that work by blocking the reverse transcriptase enzyme so that HIV cannot make new virus copies of itself; (ii) non-nucleoside reverse transcriptase inhibitors (NNRTIs), which work by blocking the enzyme reverse transcriptase and prevent reverse transcription, thus stopping HIV replication; (iii) protease inhibitors (PIs), that work by blocking the activity of protease enzymes.
Nucleotide reverse transcriptase inhibitors (NRTIs) have been used for decades to treat infection with retroviruses, such as HIV, by blocking a key enzyme which they need to make more copies of themselves.
* Nucleoside or nucleotide reverse transcriptase inhibitors (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs);
* Nucleotide reverse transcriptase inhibitors (NtRTIs) work much like NRTIs, by preventing the HIV virus from injecting its genetic code into cells.

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