The proinflammatory signaling of extracellular ATP is terminated by nucleotidases
active in the interstitial fluid and the membrane-bound ectonucleotidases, CD39 and CD73 (Fig.
Among hydrolytic enzymes proteases phospholipases (PLA) were more screened pharmacologically whilst nucleases nucleotidases
and phosphatases (acidic as well as alkaline phosphatases) were less characterized (Matsui et al.
SGPT, Serum Bile acid, GGPT and Serum nucleotidases
This protein can release 3',5',8-OH-dGDP (from modified DNA), which may subsequently be hydrolyzed to 8-OH-dGuo by nucleotidases
Other forms of 5prime nucleotidase be present in the cytoplasm and lysosomes and can be illustrious from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.
There were a significant positive correlations between alkaline, acid DNase activity and Ecto-5-prime nucleotidase with serum lead in group A [Iraqi workers employed on the operation of diesel generators] as shown in table 6.