nucleostemin

nucleostemin

,

NuclS

A protein found in stem cells, cancer cells, and dedifferentiated cells but not in mature cells dedicated to organ- or tissue-specific tasks. It is present in nucleoli and participates in cellular proliferation.
References in periodicals archive ?
Qian, "Clinical significance of nucleostemin and proliferating cell nuclear antigen protein expression in non-small cell lung cancer," Journal of B.
Can, "Continual expression throughout the cell cycle and downregulation upon adipogenic differentiation makes nucleostemin a vital human MSC proliferation marker," Stem Cell Reviews and Reports, vol.
Second, for identification, isolation and characterization of breast CSCs, self-renewal gene (OCT4, nanog, nucleostemin and SOX2) expression was investigated in drug-resistant cells by RT- PCR.
We showed that drug-resistant cells express key genes of stem cells: nanog, nucleostemin, OCT4 and SOX2.
Aberrant expression of nucleostemin activates p53 and induces cell cycle.
Mohsin et al., "Nucleostemin rejuvenates cardiac progenitor cells and antagonizes myocardial aging," Journal of the American College of Cardiology, vol.
These SNPs, rs6976 and rs11177, lie in the 3'UTR of glycosyltransferase 8 domain containing 1 (GLT8D1) and in the coding region of guanine nucleotide binding protein-like 3 (GNL3 or nucleostemin), respectively.
Expression of nucleostemin, epidermal growth factor and epidermal growth factor receptor in human esophageal squamous cell carcinoma tissues.
A recent study found that Pim-1 expression in the heart coincides with nucleostemin (NS), a nucleolar protein required for cell cycle progression and proliferation.
Species Oct-4 Nanog SOX2 SSEA-1 SSEA-4 Nucleostemin Human + + + + + Rabbit Dog + Horse + + Species CD90 CD105 CD73 CD44 CD146 CD166 CD29 CD13 Human + + + + + + + + Rabbit + + Dog + + + + Horse + + + Species sex TNC TNMD CD34 CD45 Human + + - - Rabbit - Dog - - Horse -
Further molecular studies showed that treatment of CPCs with miR-294 mimic increased AKT phosphorylation, increased protein expression of CPC multipotency marker nucleostemin [78] and pluripotency regulator LIN28 [79], and increased mRNA expression of pluripotency markers c-Myc and Klf4, as compared to miR-291 mimic and untreated controls [38].