Qian, "Clinical significance of
nucleostemin and proliferating cell nuclear antigen protein expression in non-small cell lung cancer," Journal of B.
Can, "Continual expression throughout the cell cycle and downregulation upon adipogenic differentiation makes
nucleostemin a vital human MSC proliferation marker," Stem Cell Reviews and Reports, vol.
Second, for identification, isolation and characterization of breast CSCs, self-renewal gene (OCT4, nanog, nucleostemin and SOX2) expression was investigated in drug-resistant cells by RT- PCR.
We showed that drug-resistant cells express key genes of stem cells: nanog, nucleostemin, OCT4 and SOX2.
Aberrant expression of
nucleostemin activates p53 and induces cell cycle.
Mohsin et al., "
Nucleostemin rejuvenates cardiac progenitor cells and antagonizes myocardial aging," Journal of the American College of Cardiology, vol.
These SNPs, rs6976 and rs11177, lie in the 3'UTR of glycosyltransferase 8 domain containing 1 (GLT8D1) and in the coding region of guanine nucleotide binding protein-like 3 (GNL3 or
nucleostemin), respectively.
Nucleostemin: a multiplex regulator of cell-cycle progression.
Expression of
nucleostemin, epidermal growth factor and epidermal growth factor receptor in human esophageal squamous cell carcinoma tissues.
A recent study found that Pim-1 expression in the heart coincides with
nucleostemin (NS), a nucleolar protein required for cell cycle progression and proliferation.
Species Oct-4 Nanog SOX2 SSEA-1 SSEA-4
Nucleostemin Human + + + + + Rabbit Dog + Horse + + Species CD90 CD105 CD73 CD44 CD146 CD166 CD29 CD13 Human + + + + + + + + Rabbit + + Dog + + + + Horse + + + Species sex TNC TNMD CD34 CD45 Human + + - - Rabbit - Dog - - Horse -
Further molecular studies showed that treatment of CPCs with miR-294 mimic increased AKT phosphorylation, increased protein expression of CPC multipotency marker
nucleostemin [78] and pluripotency regulator LIN28 [79], and increased mRNA expression of pluripotency markers c-Myc and Klf4, as compared to miR-291 mimic and untreated controls [38].