nucleostemin

NuclS

A protein found in stem cells, cancer cells, and dedifferentiated cells but not in mature cells dedicated to organ- or tissue-specific tasks. It is present in nucleoli and participates in cellular proliferation.

References in periodicals archive ?

Qian, "Clinical significance of nucleostemin and proliferating cell nuclear antigen protein expression in non-small cell lung cancer," Journal of B.

Standardized Uptake Values Derived from [sup.18]F-FDG PET May Predict Lung Cancer Microvessel Density and Expression of KI 67, VEGF, and HIF-1[alpha] but Not Expression of Cyclin D1, PCNA, EGFR, PD L1, and p53

Can, "Continual expression throughout the cell cycle and downregulation upon adipogenic differentiation makes nucleostemin a vital human MSC proliferation marker," Stem Cell Reviews and Reports, vol.

Mesenchymal Stromal/Stem Cells in Regenerative Medicine and Tissue Engineering

Second, for identification, isolation and characterization of breast CSCs, self-renewal gene (OCT4, nanog, nucleostemin and SOX2) expression was investigated in drug-resistant cells by RT- PCR.

We showed that drug-resistant cells express key genes of stem cells: nanog, nucleostemin, OCT4 and SOX2.

Isolation of Breast Cancer Stem Cell from MDA-MB231 Cell Line Using Vincristine/Aislamiento de Celulas Madre de Cancer de Mama de la Linea Celular MDA-MB231 utilizando Vincristina

Aberrant expression of nucleostemin activates p53 and induces cell cycle.

Immunohistochemical Surrogates for Molecular Classification of Breast Carcinoma: A 2015 Update

Mohsin et al., "Nucleostemin rejuvenates cardiac progenitor cells and antagonizes myocardial aging," Journal of the American College of Cardiology, vol.

HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation

These SNPs, rs6976 and rs11177, lie in the 3'UTR of glycosyltransferase 8 domain containing 1 (GLT8D1) and in the coding region of guanine nucleotide binding protein-like 3 (GNL3 or nucleostemin), respectively.

Epidemiology and genetics of osteoarthritis

Nucleostemin: a multiplex regulator of cell-cycle progression.

Chromosome characterization of two varieties of Mangifera indica L./Caracterizacao cromossomica de duas variedades de manga

Expression of nucleostemin, epidermal growth factor and epidermal growth factor receptor in human esophageal squamous cell carcinoma tissues.

Clinical significance of EGFR and EGFRvIII expression in human esophageal carcinoma

A recent study found that Pim-1 expression in the heart coincides with nucleostemin (NS), a nucleolar protein required for cell cycle progression and proliferation.

Current Progress in the Rejuvenation of Aging Stem/Progenitor Cells for Improving the Therapeutic Effectiveness of Myocardial Repair

Species Oct-4 Nanog SOX2 SSEA-1 SSEA-4 Nucleostemin Human + + + + + Rabbit Dog + Horse + + Species CD90 CD105 CD73 CD44 CD146 CD166 CD29 CD13 Human + + + + + + + + Rabbit + + Dog + + + + Horse + + + Species sex TNC TNMD CD34 CD45 Human + + - - Rabbit - Dog - - Horse -

Ligament-Derived Stem Cells: Identification, Characterisation, and Therapeutic Application

Further molecular studies showed that treatment of CPCs with miR-294 mimic increased AKT phosphorylation, increased protein expression of CPC multipotency marker nucleostemin [78] and pluripotency regulator LIN28 [79], and increased mRNA expression of pluripotency markers c-Myc and Klf4, as compared to miR-291 mimic and untreated controls [38].

Potential Role of Exosomes in Mending a Broken Heart: Nanoshuttles Propelling Future Clinical Therapeutics Forward