BPTF(redirected from nucleosome remodelling factor, large subunit)
BPTFA gene on chromosome 17q24.3 that encodes a histone-binding component of nucleosome-remodelling factor (NURF), a protein complex which catalyses ATP-dependent nucleosome sliding and facilitates transcription.
High levels of FAC1/BPTF may be found in foetal brain and in patients with neurodegenerative diseases (e.g., Alzheimer’s disease).
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