nucleosome

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nucleosome

 [noo´kle-o-sōm″]
any of the complexes of histone and DNA in eukaryotic cells, seen under the electron microscope as beadlike bodies on a string of DNA.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

nu·cle·o·some

(nū'klē-ō-sōm'),
A localized aggregation of histone and DNA that is evident when chromatin is in the uncondensed stage.
Synonym(s): nu body
[nucleo- + G. sōma, body]
Farlex Partner Medical Dictionary © Farlex 2012

nucleosome

(no͞o′klē-ə-sōm′, nyo͞o′-)
n.
Any of the repeating subunits of chromatin found in eukaryotes, consisting of a DNA chain coiled around a core of histones.

nu′cle·o·som′al (-sō′məl) adj.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

nucleosome

A nucleic acid and protein complex, which is the basic structural unit of chromatin, composed of a segment of DNA wrapped around a core of histone molecules.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

nu·cle·o·some

(nū'klē-ō-sōm)
A localized aggregation of histone and DNA that is evident when chromatin is in the uncondensed stage.
[nucleo- + G. sōma, body]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

nucleosome

The structural subunit of CHROMATIN consisting of about 200 BASE PAIRS and a barrel-shaped core of eight histone protein molecules (an octamer).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

nucleosome

the basic structural unit of the eukaryote chromosome, being composed of four pairs of HISTONE proteins (H2A, H2B, H3 and H4) that are combined to form an octomer around which is wrapped about 150 nucleotide pairs of DNA.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Nucleosomal restructuring by ATP-dependent chromatin remodeling complexes and enzymatic covalent histone modifications are the principal mechanisms involved in chromatin remodeling.
Moreover fucoidan reduced the viable cell number of MCF-7 cells by inducing inter nucleosomal DNA fragmentation, chromatin condensation, activation of caspases 7, 8, and 9 and cleavage of poly (ADP ribose) polymerase (220).
There is a large body of evidence showing that cellular distortion including nucleosomal fragmentation is associated with apoptosis induced by cytotoxic natural compounds [13].
Transcription initiation and elongation are associated with changes of the N-terminal region of nucleosomal H3 and H4 histone proteins in the promoter region [40, 41].
van Bruggen et al., "Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo," Journal of Clinical Investigation, vol.
HATs transfer acetyl group to [epsilon]-amino group of lysine residues in the N-terminal extensions of nucleosomal core histones.
A nucleosomal protein, HMGB1, has recently been established as a late mediator of lethal systemic inflammation with a relatively wider therapeutic window for pharmacological interventions.
Mechanisms inducing sperm DNA damage: During sperm nuclear condensation, a dramatic sequence of events occurs involving topological rearrangements, transition of DNA-binding proteins, alterations in transcription and loss of nucleosomal structure.
A positive role for histone acetylation in transcription factor access to nucleosomal DNA.
Part of this is accomplished by the high degree of condensation of sperm chromatin in these genetically silent cells, which is attributable to the substitution during spermatogenesis of various DNA-packaging basic proteins for the nucleosomal histones found in somatic cells.
One of the hallmarks of apoptotic KB cells (treated with GSE) was the presence of nucleosomal DNA fragments, confirmed by TUNEL assay.
We observed that EGCG induced apoptosis in human lymphoma U937 cells as evidenced by the events including formation of apoptotic bodies and degradation of DNA into nucleosomal units.

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