nucleoside reverse transcriptase inhibitors


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Related to nucleoside reverse transcriptase inhibitors: Protease inhibitors

nu·cle·o·side re·verse tran·scrip·tase in·hib·i·tors

(NRTIs) (nyū'klē-ō-sīd rĕ-vĕrs' trans-krip'tās in-hib'i-tŏrz)
Class of medications to treat HIV infection (e.g., zidovudine, lamivudine).

nucleoside reverse transcriptase inhibitors

Drugs used to treat HIV infections in combination with other drugs. Examples are abacavir (Ziagen), didanosine (Videx, Videx EC), lamivudine (Combivir, Epivir), stavudine (Zerit), zalcitabine (Hivid) and zidovudine (Retrovir). The brand Trizivir contains abacavir, lamivudine and zidovudine.
References in periodicals archive ?
The recommended regimen is based on two NRTIS (nucleoside reverse transcriptase inhibitor) plus an NNRTI (Non-nucleoside reverse transcriptase inhibitor) or boosted Protease inhibitor.
As with all members of this drug class (nucleoside reverse transcriptase inhibitors), the prescribing information carries a black-box warning about risk of lactic acidosis and liver toxicity.
The guidelines advocate initial treatment regimens that consist of two nucleoside reverse transcriptase inhibitors (NR-TIs) plus either the non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz or a ritonavir-boosted protease inhibitor (PI/r).
The study, which looked at the effect of five individual nucleoside reverse transcriptase inhibitors (NRTIs), showed that treatment with abacavir (Ziagen) was associated with a 90% increased risk of Ml, and didanosine was associated with a 49% increased risk.
However, while we know resistance can slow this virus down--we all know resistant virus can win; look at what happened in the era of treating with just nucleoside reverse transcriptase inhibitors (NRTIs) and the ongoing deaths from uncontrolled HIV.
Eviplera combines Gilead's Truvada, a fixed-dose combination of the two nucleoside reverse transcriptase inhibitors emtricitabine 200 mg and tenofovir disoproxil 245 mg, and Tibotec Pharmaceuticals' rilpivirine 25 mg, marketed by Janssen-Cilag International NV as Edurant.
Currently, the primary classes of HIV drugs are protease inhibitors (PIs), nucleoside reverse transcriptase inhibitors (NRTIs), and nonnucleoside reverse transcriptase inhibitors (NNRTIs).
Newer drugs are selecting for different types of resistance, especially in nucleoside reverse transcriptase inhibitors (NRTIs), so that there may not be large numbers of thymidine analog mutations (TAMs) developing in patients who have started therapy in recent years.
The patients in this study received an optimal background regimen of nucleoside reverse transcriptase inhibitors, with or without enfuvirtide.
Surprisingly, support for this notion has come from testing the effect of removing single drugs from a failing regimen--in particular, nucleoside reverse transcriptase inhibitors (NRTIs).

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