nucleoside reverse transcriptase inhibitor


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

nucleoside reverse transcriptase inhibitor

n. Abbr. NRTI
Any of a group of antiviral drugs, such as stavudine, that interfere with the activity of the enzyme reverse transcriptase, are structural analogs of natural nucleosides, and are used chiefly to treat HIV infection.

nucleoside reverse transcriptase inhibitor

Abbreviation: NRTI
Any of a class of antiretroviral drugs used to treat patients with HIV infection. NRTIs prevent transcription of viral RNA to host DNA by interfering with the action of the enzyme reverse transcriptase. Zidovudine, dideoxyinosine, zalcitabine, d4T, and abacavir are NRTIs. See: reverse transcriptase inhibitor
See also: inhibitor
References in periodicals archive ?
[1.] Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration.
Bone densities were retested after 48 weeks of combination HIV therapy with a nonnucleoside reverse transcriptase inhibitor (NNRTI) and nucleoside reverse transcriptase inhibitors (NRTIs), or an NNRTI and a boosted protease inhibitor, or two NRTIs and a boosted protease inhibitor.
The survey, which looked at specimens from 3,130 newly diagnosed, drug-naive individuals, found that 4% of infections had mutations conferring resistance to nucleoside reverse transcriptase inhibitors, 7% to nonnucleoside reverse transcriptase inhibitors, and 2% to protease inhibitors.
A typical anti-HIV cocktail consists of one protease inhibitor, such as Kaletra or Viracept, and two nucleoside reverse transcriptase inhibitors, such as Zerit, Retrovir, and Videx.
ATLAS was designed to establish if HIV-1-infected adult participants who had maintained viral suppression for at least six months, on a daily oral regimen comprised of two nucleoside reverse transcriptase inhibitors plus a third agent, maintained similar rates of viral suppression upon switching to the investigational, two-drug, long-acting, injectable regimen of cabotegravir and rilpivirine, compared with continuing the three-drug oral regimen.
The study, which looked at the effect of five individual nucleoside reverse transcriptase inhibitors (NRTIs), showed that treatment with abacavir (Ziagen) was associated with a 90% increased risk of Ml, and didanosine was associated with a 49% increased risk.
As with all members of this drug class (nucleoside reverse transcriptase inhibitors), the prescribing information carries a black-box warning about risk of lactic acidosis and liver toxicity.
The guidelines advocate initial treatment regimens that consist of two nucleoside reverse transcriptase inhibitors (NR-TIs) plus either the non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz or a ritonavir-boosted protease inhibitor (PI/r).
After 24 weeks, the combination of Invirase, Agenerase, and Norvir plus nucleoside reverse transcriptase inhibitors (NRTIs or "nukes") decreased viral load and increased T cell count.
Currently, the primary classes of HIV drugs are protease inhibitors (PIs), nucleoside reverse transcriptase inhibitors (NRTIs), and nonnucleoside reverse transcriptase inhibitors (NNRTIs).
The patients in this study received an optimal background regimen of nucleoside reverse transcriptase inhibitors, with or without enfuvirtide.

Full browser ?