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Related to nucleoside analogue: ribavirin, Nucleotide analog, Nucleoside analogue reverse transcriptase inhibitors
1. a part or organ having the same function as another, but of different evolutionary origin.
2. a chemical compound having a structure similar to that of another but differing from it in respect to a certain component; it may have similar or opposite action metabolically. Also spelled analog.
nucleoside analogue a structural analogue of a nucleoside, a category that includes both purine analogues and pyrimidine analogues.
purine analogue a structural analogue of one of the purine bases(purine, adenine, or guanine); mercaptopurine and thioguanine are used as antineoplastics and azathioprine is an immunosuppressive. The antiviral agent vidarabine is an analogue of the adenine nucleoside adenosine.
pyrimidine analogue a structural analogue of one of the pyrimidine bases(cytosine, thymine, or uracil); fluorouracil and cytarabine are important antineoplastic agents.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
nucleoside analogueMolecular medicine An artificial nucleoside which, when incorporated into viral DNA during replication, prevents production of new virus; NAs can inhibit DNA production in healthy cells; a molecule that structurally mimics a nucleoside. See AIDS, Zidovudine.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
nucleoside analogueA drug that resembles a NUCLEOSIDE and that can be taken up in place of the natural nucleosides in viruses so as to form DNA that is fragile and susceptible to breakage. Drugs of this class, which include IDOXURIDINE, FAMCICLOVIR, DIDANOSINE and PENCICLOVIR, require the action of an enzyme carried by the target virus, before they become functional.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005