Current therapies with nucleoside analogues
achieve remission in most patients.
Symbol Variables -1.6818 Code level 1.6818 -1 0 1 [X.sub.1] Sucrose (g/L) 3.1821 10 20 30 36.8179 [X.sub.4] [K.sub.2] 0.1591 0.5 1 1.5 1.8409 HP[O.sub.4] x 3H2O (g/L) [X.sub.6] MgS[O.sub.4] x 0.1591 0.5 1 1.5 1.8409 7[H.sub.2]O (g/L) TABLE 4: Factors and levels of central composite design for amino acid, nucleoside analogue
, and time.
There was no HBV graft reinfection or HB recurrence in the 24 cases who discontinued HBIG during the followup period of 26.13 [+ or -] 7.05 months (median: 24.5 months; range: 19 to 52 months), and 21 cases discontinued both HBIG and nucleoside analogues
during the follow-up period of 39.86 [+ or -] 15.47 months (median: 34 months; range: 20 to 87 months).
Reverse Transcriptase Inhibitors Generic Name Initials Trade Name Manufacturer Didanosine (1990) ddl Videx Bristol-Myers Squibb Lamivudine (1995) 3TC Epivir Glaxo Wellcome Stavudine (1994) d4T Zerit Bristol-Myers Squibb Zalcitabine (1992) ddC HIVID Hoffmann-LaRoche Zidovudine (1987) AZT/ZDV Retrovir Glaxo Wellcome Table 2.
The treatment regimens of both groups also included two different nucleoside analogue
reverse transcriptase inhibitors (NRTI).
To determine the absolute risk of MI among nucleoside analogue
users, the investigators incorporated the Framingham predicted 10-year coronary heart disease risk into the main regression model, and determined that the rate of MI was increased by 119% in patients with a moderate 10-year risk and by 222% in patients with a high 10-year risk, relative to those with a low 10-year risk, Dr.
Currently, the antifungal armamentarium permits physicians to attack only two targets: The fungal cell membrane can be addressed using amphotericin, a first-generation triazole, or terbinafine, or cell metabolism can be disrupted via a nucleoside analogue
The product is an orally-available nucleoside analogue
that acts through a novel DNA single-strand breaking mechanism, resulting in production of DNA double strand breaks and/or checkpoint activation.
The nucleoside analogue
entecavir has been approved by the Food and Drug Administration for treating chronic hepatitis B in adults with decompensated liver disease, the manufacturer announced.
Nucleoside-sparing regimens have been studied for over a decade [5,9-14], and have several potential advantages, as they avoid nucleoside analogue
toxicity, and preserve this class of drug for later lines of therapy.
Ribavirin, a nucleoside analogue
, is licensed to Schering-Plough (Kenilworth, NJ) and marketed in combination with Schering-Plough's interferon alfa-2b product (Rebetron) and with pegylated interferon alfa-2b (PEG-Intron -- Rebetol) for the treatment of chronic hepatitis C.
Sustiva will now be available as a 600 mg tablet to be taken once daily, in combination with a protease inhibitor and/or nucleoside analogue
reverse transcriptase inhibitors (NRTIs).