nucleoside analogue


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.
Related to nucleoside analogue: ribavirin, Nucleotide analog, Nucleoside analogue reverse transcriptase inhibitors

analogue

 [an´ah-log]
1. a part or organ having the same function as another, but of different evolutionary origin.
2. a chemical compound having a structure similar to that of another but differing from it in respect to a certain component; it may have similar or opposite action metabolically. Also spelled analog.
nucleoside analogue a structural analogue of a nucleoside, a category that includes both purine analogues and pyrimidine analogues.
purine analogue a structural analogue of one of the purine bases(purine, adenine, or guanine); mercaptopurine and thioguanine are used as antineoplastics and azathioprine is an immunosuppressive. The antiviral agent vidarabine is an analogue of the adenine nucleoside adenosine.
pyrimidine analogue a structural analogue of one of the pyrimidine bases(cytosine, thymine, or uracil); fluorouracil and cytarabine are important antineoplastic agents.

nucleoside analogue

Molecular medicine An artificial nucleoside which, when incorporated into viral DNA during replication, prevents production of new virus; NAs can inhibit DNA production in healthy cells; a molecule that structurally mimics a nucleoside. See AIDS, Zidovudine.

nucleoside analogue

A drug that resembles a NUCLEOSIDE and that can be taken up in place of the natural nucleosides in viruses so as to form DNA that is fragile and susceptible to breakage. Drugs of this class, which include IDOXURIDINE, FAMCICLOVIR, DIDANOSINE and PENCICLOVIR, require the action of an enzyme carried by the target virus, before they become functional.
References in periodicals archive ?
Nucleoside analogues are usually administered for at least 6 months after the patient has developed anti-HBe, in HBeAg-positive patients, and until clearance of HBsAg in HBeAgnegative patients.
These preliminary data provide promise that the combination of Combivir+Ziagen may effectively suppress HIV replication in patients previously treated with other nucleoside analogues," said Keith Henry, M.
Clinical data indicated that patients receiving indinavir alone or in combination with nucleoside analogues experienced a marked increase in their CD4 levels and had a marked decrease in their viral load.
Nucleoside analogues are used and developed for the treatment of several life threatening viral infections, including HIV-1 and HCV.
Approved June 24, 1996 for use in combination with nucleoside analogues for the treatment of HIV-infected adults experiencing clinical and/or immunologic deterioration.
Patient access to current and new nucleoside analogues is improving and more patients are anticipated to gain access to drug treatments.
five who received nucleoside analogues and 18 who were untreated (Lancet 362[9397]:1708-13, 2003).
A trend toward higher weight loss was seen in patients who received didanosine or stavudine, compared with those who received other nucleoside analogues (N.
This combination product should only be used by those whose treatment regimens would otherwise include these doses of these three nucleoside analogues.
Investigators reported results of a 24-week, Phase IIB, Merck-sponsored study of MK-0518 in patients with resistance to protease inhibitors, nucleoside analogues and non-nucleoside analogues.
Quadruple therapy with two nucleoside analogues plus nelfinavir and efavirenz improved treatment response in a recent study of HIV-infected patients who failed treatment with nucleoside analogues alone.
NNRTIs, nucleoside analogues, protease inhibitors), across classes, and with HIV positive patients who are not receiving therapy.

Full browser ?