nucleoside analogue


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analogue

 [an´ah-log]
1. a part or organ having the same function as another, but of different evolutionary origin.
2. a chemical compound having a structure similar to that of another but differing from it in respect to a certain component; it may have similar or opposite action metabolically. Also spelled analog.
nucleoside analogue a structural analogue of a nucleoside, a category that includes both purine analogues and pyrimidine analogues.
purine analogue a structural analogue of one of the purine bases(purine, adenine, or guanine); mercaptopurine and thioguanine are used as antineoplastics and azathioprine is an immunosuppressive. The antiviral agent vidarabine is an analogue of the adenine nucleoside adenosine.
pyrimidine analogue a structural analogue of one of the pyrimidine bases(cytosine, thymine, or uracil); fluorouracil and cytarabine are important antineoplastic agents.

nucleoside analogue

Molecular medicine An artificial nucleoside which, when incorporated into viral DNA during replication, prevents production of new virus; NAs can inhibit DNA production in healthy cells; a molecule that structurally mimics a nucleoside. See AIDS, Zidovudine.

nucleoside analogue

A drug that resembles a NUCLEOSIDE and that can be taken up in place of the natural nucleosides in viruses so as to form DNA that is fragile and susceptible to breakage. Drugs of this class, which include IDOXURIDINE, FAMCICLOVIR, DIDANOSINE and PENCICLOVIR, require the action of an enzyme carried by the target virus, before they become functional.
References in periodicals archive ?
Current therapies with nucleoside analogues achieve remission in most patients.
Symbol Variables -1.6818 Code level 1.6818 -1 0 1 [X.sub.1] Sucrose (g/L) 3.1821 10 20 30 36.8179 [X.sub.4] [K.sub.2] 0.1591 0.5 1 1.5 1.8409 HP[O.sub.4] x 3H2O (g/L) [X.sub.6] MgS[O.sub.4] x 0.1591 0.5 1 1.5 1.8409 7[H.sub.2]O (g/L) TABLE 4: Factors and levels of central composite design for amino acid, nucleoside analogue, and time.
There was no HBV graft reinfection or HB recurrence in the 24 cases who discontinued HBIG during the followup period of 26.13 [+ or -] 7.05 months (median: 24.5 months; range: 19 to 52 months), and 21 cases discontinued both HBIG and nucleoside analogues during the follow-up period of 39.86 [+ or -] 15.47 months (median: 34 months; range: 20 to 87 months).
Nucleoside Analogue Reverse Transcriptase Inhibitors Generic Name Initials Trade Name Manufacturer Didanosine (1990) ddl Videx Bristol-Myers Squibb Lamivudine (1995) 3TC Epivir Glaxo Wellcome Stavudine (1994) d4T Zerit Bristol-Myers Squibb Zalcitabine (1992) ddC HIVID Hoffmann-LaRoche Zidovudine (1987) AZT/ZDV Retrovir Glaxo Wellcome Table 2.
The treatment regimens of both groups also included two different nucleoside analogue reverse transcriptase inhibitors (NRTI).
To determine the absolute risk of MI among nucleoside analogue users, the investigators incorporated the Framingham predicted 10-year coronary heart disease risk into the main regression model, and determined that the rate of MI was increased by 119% in patients with a moderate 10-year risk and by 222% in patients with a high 10-year risk, relative to those with a low 10-year risk, Dr.
Currently, the antifungal armamentarium permits physicians to attack only two targets: The fungal cell membrane can be addressed using amphotericin, a first-generation triazole, or terbinafine, or cell metabolism can be disrupted via a nucleoside analogue.
The product is an orally-available nucleoside analogue that acts through a novel DNA single-strand breaking mechanism, resulting in production of DNA double strand breaks and/or checkpoint activation.
The nucleoside analogue entecavir has been approved by the Food and Drug Administration for treating chronic hepatitis B in adults with decompensated liver disease, the manufacturer announced.
Nucleoside-sparing regimens have been studied for over a decade [5,9-14], and have several potential advantages, as they avoid nucleoside analogue toxicity, and preserve this class of drug for later lines of therapy.
Ribavirin, a nucleoside analogue, is licensed to Schering-Plough (Kenilworth, NJ) and marketed in combination with Schering-Plough's interferon alfa-2b product (Rebetron) and with pegylated interferon alfa-2b (PEG-Intron -- Rebetol) for the treatment of chronic hepatitis C.
Sustiva will now be available as a 600 mg tablet to be taken once daily, in combination with a protease inhibitor and/or nucleoside analogue reverse transcriptase inhibitors (NRTIs).

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