nucleoside analog reverse transcriptase inhibitor


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nucleoside analog reverse transcriptase inhibitor

NRTI, NARTI, "nuke" AIDS A class of drugs that includes AZT–Retrovir, ddI–Videx, ddC–HIVID, d4T–Zerit, 3TC–Epivir, abacavir–Ziagen; reverse transcriptase is the part of HIV that assembles viral DNA; NRTIs inhibit reverse transcriptase by acting as 'dummy' nucleosides. See AIDS.
References in periodicals archive ?
Reverset was also shown to be effective in patients with virus resistant to other commonly used nucleoside analog reverse transcriptase inhibitors (NRTIs), including viruses harboring multiple thymidine analog mutations (TAMS), including the M41L and L210W mutations, and the L74V and M184V mutations.
Many people did not achieve durable virologic benefits from these drugs, mainly because they had previously taken and developed resistance to the nucleoside analog reverse transcriptase inhibitors (NRTIs).
The program will make adefovir dipivoxil available free of charge to HIV-positive patients at least 13 years of age who have failed treatment with at least two nucleoside analog reverse transcriptase inhibitors and one protease inhibitor, regardless of their HIV RNA plasma level or CD4 cell count.
The program makes PREVEON available free of charge to HIV infected adults in the United States who have failed treatment with at least two nucleoside analog reverse transcriptase inhibitors and one protease inhibitor.

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