nucleoside analog


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Related to nucleoside analog: Purine nucleoside phosphorylase

nucleoside analog

n.
Any of a group of synthetic compounds that are structurally similar to natural nucleosides and interfere with DNA or RNA synthesis, used as antiviral and anticancer drugs.
References in periodicals archive ?
Sapacitabine (CYC682), a cell cycle modulating nucleoside analog, will be entering Phase 3 development for the treatment of acute myeloid leukemia in the elderly under a Special Protocol Assessment agreement with the U.S.
Emtricitabine (Emtriva[R], Gilead Sciences) is a nucleoside analog that is structurally related to lamivudine.
Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. J Biol Chem.
KP-1461 is a nucleoside analog, like AZT, 3TC, and the others; once inside the cell it is chemically modified (triphosphorylated) into its active form (called KP-1212), which can replace one of the four bases used to make DNA.
Most countries in southern Africa have limited regimens based on nucleoside analog reverse transcriptase inhibitor (NRTI) backbones combined with either a non-NRTI (nNRTI) or a protease inhibitor (PI).
Reverset was also shown to be effective in patients with virus resistant to other commonly used nucleoside analog reverse transcriptase inhibitors (NRTIs), including viruses harboring multiple thymidine analog mutations (TAMS), including the M41L and L210W mutations, and the L74V and M184V mutations.
Many people did not achieve durable virologic benefits from these drugs, mainly because they had previously taken and developed resistance to the nucleoside analog reverse transcriptase inhibitors (NRTIs).
Studies show that anti-HIV drugs, especially nucleoside analog drugs, or nukes, lead to a loss of mitochondriat DNA and cell damage.
Zidovudine is a nucleoside analog. It is a reverse transcriptase inhibitor.
NUC-7738 is NuCana's ProTide transformation of 3'-deoxyadenosine, a novel nucleoside analog with a unique mode of action, that has shown potent anti-cancer activity in preclinical studies.
Clevudine is an oral, once-daily nucleoside analog drug candidate for the treatment of HBV that was shown to be well tolerated and potent in previously completed clinical studies.

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