nucleic acid probe

nu·cle·ic ac·id probe

a nucleic acid fragment, labeled by a radioisotope, biotin, and the like, which is complementary to a sequence in another nucleic acid (fragment) and that will, by hydrogen binding to the latter, locate or identify it and be detected; a diagnostic technique based on the fact that every species of microbe possesses some unique nucleic acid sequences that differentiate it from all others, and thus can be used as identifying markers or "fingerprints."

nucleic acid probe

(noo-klē′ik, nū-)
A labelled single-strand of DNA used to detect complementary DNA in a laboratory specimen.

nucleic acid probe

see PROBE.
References in periodicals archive ?
Nucleic acid probe technology provides information for diagnosis, determining prognosis, selecting therapeutic modalities, and monitoring disease progression.
An in vitro target amplification-based nucleic acid probe test that detects HCV RNA in human plasma and serum utilizing Transcription-Mediated Amplification (TMA).
Policar noted that nucleic acid probe tests are not as accurate as the NAATs, and clinicians using these tests should consider switching to a NAAT system.
* Expanded diagnostic options will include the OSOM Trichomonas rapid test (an immunochromatographic capillary flow / dipstick assay) and the Affirm VP III nucleic acid probe test.
All these methods use electric fields to separate DNA fragments, whole chromosomes, or plasmids into unique patterns or fingerprints that are visualized by staining with ethidium bromide or by nucleic acid probe hybridization (Figure 1).
The broadly claimed methods result in a substantial reduction in the non-specific signal in the assay as compared with conventional nucleic acid probe based hybridization assays to thereby improve the performance of the probe based assays far beyond that obtainable by mere optimization of stringency conditions.
patent application, among other uses, covers compositions and processes for trapping nucleic acid on solid supports, a process used in the majority of nucleic acid probe test now being performed.
The nucleic acid probe test for vaginal infection, which was removed from the market following the study, performed better than did clinicians' microscopic tests.
Part One covers general and basic techniques, and includes such subjects as rapid methods and automation, testing and use of the results, sample removal and preparation, enumeration, evaluation of microflora by nonmicrological methods, identification, applications of immunology, using nucleic acid probe hybridization and prediction of product lifespan.
Another format uses a nucleic acid probe specific to Listeria to identify any of those organisms present after enrichment by using chemicals that become colored only in the presence of the bacteria.
* Expanded diagnostic options will include the OSOM Trichomonas rapid test (an immunochromatographic capillary flow/dipstick assay) and the Affirm VP III nucleic acid probe test.
Our recent findings suggest that up to ten times more of nucleic acid probe can be loaded onto proprietary silane surfaces compared to other methodologies such as the avidin-biotin system or common silanes, while still retaining a monolayer-like structure.