Cytology, as well as further core needle biopsy samples, revealed thyroid tissue infiltrated by blast-like cells with a high nuclear-to-cytoplasmic ratio
, a fine chromatin pattern, and variable prominent nucleoli.
Enlarged vesicular nuclei with prominent nucleoli, spindling of tumor cells, high nuclear-to-cytoplasmic ratio
, nuclear pleomorphism, appreciable mitotic activity, and tumor necrosis should be suspicious of malignant GCT.
In the study group A, cytomorphometric changes of exfoliative palatal epithelial cells of excrescences (Case group I) showed significant increase in Mean Nuclear Diameter (ND), Cell Diameter (CD) and nuclear-to-cytoplasmic ratio
(N:C) compared to red patches and white patches (TukeyHSD procedure--significant at 5% level) (Table 1).
Histopathological examination revealed a polypoid neoplastic growth with focal glandular, tubulocystic and pseudopapillary patterns (figures 2 C, D case 2) composed of large clear cells that had high nuclear-to-cytoplasmic ratio
, hyperchromasia, irregular nuclear membranes and frequent mitoses (figures 2A, B case 2).
Examination of the patient's peripheral blood sample on the first day post partum revealed the presence of numerous blast cells with high nuclear-to-cytoplasmic ratio
, irregular nuclei, finely reticular chromatin, and 1 to 4 nucleoli (Figure 1, A and B).
The cells had a high nuclear-to-cytoplasmic ratio
, and profiles of intermediate filaments were prevalent in the cytoplasm of the cells (Figure 2B,C).
Typical carcinoid grows in ribbons, nests, and festoons of relatively small to medium cells showing an intermediate nuclear-to-cytoplasmic ratio
and round nuclei with delicate, salt-and-pepper nuclear chromatin distribution.
The neoplastic cells have a very high nuclear-to-cytoplasmic ratio
, with nuclei that are delicate and prone to crush artifacts.
The cells are slightly enlarged, and there is a high nuclear-to-cytoplasmic ratio
, very little maturation toward the surface, and at least a few areas of loss of polarity (figure 2).
enlarged cells with a high nuclear-to-cytoplasmic ratio
The cells have a relatively high nuclear-to-cytoplasmic ratio
and hyperchromatic nuclei (figure 2).
Morphologically, the neoplasm is characterized by monotonous sheets of hyperchromatic cells with round-to-oval nuclei, high nuclear-to-cytoplasmic ratios
, and scant cytoplasm.