They have a tubular configuration and low nuclear-cytoplasmic ratio
with little or no intervening stroma (Figures 1(a)-1(c)) [2, 8].
Fine-needle aspiration cytology of the cutaneous nodules revealed a heterogeneous, clear cell population arranged in loose clusters and singles showing cytoplasmic vacuolation, high nuclear-cytoplasmic ratio
. A tentative diagnosis of metastatic deposits of clear cell carcinoma, most probably renal in origin was made.
For example, in mild dysplasia, where the nuclear-cytoplasmic ratio
was shifted more in favor of the nucleus, the contours of the nuclei were irregular chromatin, was moderately hyperchromatic, and had a grainy appearance.
Basaloid cells: tight clusters or singly occurring, small cells having a high nuclear-cytoplasmic ratio
, round to oval nuclei with smooth nuclear borders, finely dispersed to slightly granular chromatin, conspicuous to prominent nucleoli and unapparent cytoplasm.
Large atypical lymphoid cells with high nuclear-cytoplasmic ratio
and apoptosis, indicating transformation into an aggressive lymphoma such as diffuse large B-cell lymphoma, were partly observed (Fig.
in neurons, density of the neuroglia, as well as the overall total area of microcirculatory blood stream (MCBS), were determined by a point method.
These features include luminal epithelial cells with at least subtle atypia in the form of nuclear enlargement, higher nuclear-cytoplasmic ratio
, and hyperchromatic nuclei (Figure 1, F; Figure 2, C and D; Figure 3, E and F; Figure 4, A through D).
(2) FNAC of the swelling reported as " Spindle cell lesion with altered Nuclear-Cytoplasmic ratio
with binucleate cells & myxoid areas".
Under low magnification, the tumor is characterized by variably sized clusters of epithelial cells with large nuclei that are surrounded by a relatively abundant amount of cytoplasm; hence, a relatively low nuclear-cytoplasmic ratio
of the neoplastic cells.
The lining epithelium showed stratification, loss of nuclear polarity, atypia, high nuclear-cytoplasmic ratio
, nuclear hyperchromasia and abnormal mitotic figures.
The nuclear-cytoplasmic ratio
is lower than that of traditional adenomas.
Also seen were neuroblasts having high nuclear-cytoplasmic ratio
with round nucleus and stippled chromatin.