nuclear-cytoplasmic ratio

nu·cle·ar-·cy·to·plas·mic ra·ti·o

ratio of volume of nucleus to volume of cytoplasm, fairly constant for a particular cell type and usually increased in malignant neoplasms.

nuclear-cytoplasmic ratio

A crude parameter used in cytology and surgical pathology, in which interphase (i.e., nondividing) nuclei are proportionately larger than the surrounding cytoplasm, a finding which is often increased in malignant cells.
References in periodicals archive ?
Large atypical lymphoid cells with high nuclear-cytoplasmic ratio and apoptosis, indicating transformation into an aggressive lymphoma such as diffuse large B-cell lymphoma, were partly observed (Fig.
Morphologically, the acini in these p63-positive carcinomas frequently appear atrophic, with a high nuclear-cytoplasmic ratio and a basaloid appearance (Figure 1, E).
These features include luminal epithelial cells with at least subtle atypia in the form of nuclear enlargement, higher nuclear-cytoplasmic ratio, and hyperchromatic nuclei (Figure 1, F; Figure 2, C and D; Figure 3, E and F; Figure 4, A through D).
Under low magnification, the tumor is characterized by variably sized clusters of epithelial cells with large nuclei that are surrounded by a relatively abundant amount of cytoplasm; hence, a relatively low nuclear-cytoplasmic ratio of the neoplastic cells.
Granular cell tumors (GCTs) are classified as benign when none of the following features is present: spindling of the tumor cells, necrosis, diffuse pleomorphism, prominent nucleoli, high nuclear-cytoplasmic ratio, and mitotic rate >2 per 10 high-power fields.
We examined multiple sections and found no evidence of cellular pleomorphism, changes in nuclear-cytoplasmic ratio, nuclear hyperchromasia, or mitotic activity.
However, markedly enlarged pleomorphic cells were present, exhibiting pleomorphism, a high nuclear-cytoplasmic ratio, hyperchromatic nuclei, smudged chromatin, and conspicuous nucleoli.
In serrated adenomas, the nuclear-cytoplasmic ratio exceeds that of typical hyperplastic polyps, the nuclei show pseudostratification, and mitoses may be present in the upper portion of the crypt or even in the surface epithelium.
Peripheral blood examination showed the presence of a monotonous population of blasts with multiple prominent nucleoli, finely dispersed chromatin, and a high nuclear-cytoplasmic ratio.
The nuclear-cytoplasmic ratio was high and the cytoplasm was amphophilic.
3] For this reason it has been suggested that the possibility of aggressive clinical behavior must be considered in a granular cell tumor showing scattered mitoses, nuclear pleomorphism, spindling, or a high nuclear-cytoplasmic ratio.

Full browser ?