Fine-needle aspiration cytology of the cutaneous nodules revealed a heterogeneous, clear cell population arranged in loose clusters and singles showing cytoplasmic vacuolation, high nuclear-cytoplasmic ratio
For example, in mild dysplasia, where the nuclear-cytoplasmic ratio
was shifted more in favor of the nucleus, the contours of the nuclei were irregular chromatin, was moderately hyperchromatic, and had a grainy appearance.
The increase in intracellular resistivity can be explained because of the narrowing of the pathways for current flow in the cytoplasm, due to the increase in nuclear size and the nuclear-cytoplasmic ratio
when intraepithelial neoplasia is present.
Basaloid cells: tight clusters or singly occurring, small cells having a high nuclear-cytoplasmic ratio
, round to oval nuclei with smooth nuclear borders, finely dispersed to slightly granular chromatin, conspicuous to prominent nucleoli and unapparent cytoplasm.
Large atypical lymphoid cells with high nuclear-cytoplasmic ratio
and apoptosis, indicating transformation into an aggressive lymphoma such as diffuse large B-cell lymphoma, were partly observed (Fig.
in neurons, density of the neuroglia, as well as the overall total area of microcirculatory blood stream (MCBS), were determined by a point method.
These features include luminal epithelial cells with at least subtle atypia in the form of nuclear enlargement, higher nuclear-cytoplasmic ratio
, and hyperchromatic nuclei (Figure 1, F; Figure 2, C and D; Figure 3, E and F; Figure 4, A through D).
2) FNAC of the swelling reported as " Spindle cell lesion with altered Nuclear-Cytoplasmic ratio
with binucleate cells & myxoid areas".
Under low magnification, the tumor is characterized by variably sized clusters of epithelial cells with large nuclei that are surrounded by a relatively abundant amount of cytoplasm; hence, a relatively low nuclear-cytoplasmic ratio
of the neoplastic cells.
The lining epithelium showed stratification, loss of nuclear polarity, atypia, high nuclear-cytoplasmic ratio
, nuclear hyperchromasia and abnormal mitotic figures.
The nuclear-cytoplasmic ratio
is lower than that of traditional adenomas.
Also seen were neuroblasts having high nuclear-cytoplasmic ratio
with round nucleus and stippled chromatin.