It also demonstrates the cytoplasmic nature of the nuclear pseudoinclusions
. (7, 12)
Nuclear findings included perinucleolar clearing, nuclear pseudoinclusions
, and nuclear grooves.
venous invasion, capsular invasion, tumor necrosis, >45mitoses/50hpf, atypical mitoses, high nuclear grade, nuclear pseudoinclusions
and diffuse architecture of tumor cells amongst others.
and psammoma bodies, which are characteristic histologic features of meningiomas, are not observed in HPCs.12 Both meningiomas and HPCs are vimentin positive, suggesting a mesenchymal origin.
Histologically, FDCS is composed of uniform, spindle and ovoid cells, with eosinophilic cytoplasm and nuclei with a vesicular chromatin pattern, nuclear pseudoinclusions
, and distinct nucleoli (Figure 2).
The morphologic affinities between hyalinising trabecular tumor and papillary carcinoma, including nuclear pseudoinclusions
and grooves, suggest that these tumor may be of similar origin (2).
These cells form syncytia and are characterized by oval nuclei, fine chromatin, distinct nucleoli, and occasional nuclear pseudoinclusions
can occasionally be seen, with frequency increased after radiation therapy.
The aim was to ascertain an IHC antibody capable of identifying the most specific feature of PTC: nuclear pseudoinclusions
. Our hypothesis is based on the pathomor phogenesis of these structures, which consists of a nuclear membrane that progressively envelops a cytoplasmic drop.
The epithelioid cells have small, bland nuclei; prominent, pale nuclear pseudoinclusions
; and abundant eosinophilic cytoplasm, and they stain diffusely with S100.
The largest lymph node (4 cm) displayed an effaced architecture by wildly pleomorphic epithelioid cells with bizarre nuclei; large, cherry-red macronucleoli; occasional nuclear pseudoinclusions
; and variable amounts of dusty cytoplasmic pigment, consistent with metastatic melanoma (Figure 1, A).
Dutcher bodies are PAS-positive, diastase-resistant nuclear pseudoinclusions
of eosinophilic cytoplasm found in plasma cells described by Dutcher and Fahey (2) in Waldenstrom macroglobulinemia.