nuclear pseudoinclusion

nuclear pseudoinclusion

A finding by electron microscopy in the nuclei of malignant epithelial cells, in which a “bleb” of cytoplasm prolapses into the nucleus, simulating an intranuclear inclusion.
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Histologically, FDCS is composed of uniform, spindle and ovoid cells, with eosinophilic cytoplasm and nuclei with a vesicular chromatin pattern, nuclear pseudoinclusions, and distinct nucleoli (Figure 2).
Nuclear findings included perinucleolar clearing, nuclear pseudoinclusions, and nuclear grooves.
venous invasion, capsular invasion, tumor necrosis, >45mitoses/50hpf, atypical mitoses, high nuclear grade, nuclear pseudoinclusions and diffuse architecture of tumor cells amongst others.
Nuclear pseudoinclusions and psammoma bodies, which are characteristic histologic features of meningiomas, are not observed in HPCs.
Nuclear pseudoinclusions can occasionally be seen, with frequency increased after radiation therapy.
The morphologic affinities between hyalinising trabecular tumor and papillary carcinoma, including nuclear pseudoinclusions and grooves, suggest that these tumor may be of similar origin (2).
These cells form syncytia and are characterized by oval nuclei, fine chromatin, distinct nucleoli, and occasional nuclear pseudoinclusions.
Furthermore, [beta]-catenin marked nuclear pseudoinclusions in 44% of cases in the TMA series (ISE Galileo CK 4500, Integrated Systems Engineering, Milan, Italy).
Dutcher bodies are PAS-positive, diastase-resistant nuclear pseudoinclusions of eosinophilic cytoplasm found in plasma cells described by Dutcher and Fahey (2) in Waldenstrom macroglobulinemia.
The unexpected finding within the cyst of a papillary proliferation with optically clear nuclei, nuclear grooves, and nuclear pseudoinclusions is diagnostic of papillary carcinoma arising in the thyroglossal duct cyst.
The cysts were lined by cuboidal epithelial cells with moderate amounts of eosinophilic cytoplasm and large oval nuclei with occasional nuclear pseudoinclusions (Figure 2).
Microscopically, PXA is characterized by neoplastic astrocytes that show marked nuclear pleomorphism, rare-to-absent mitotic figures, nuclear pseudoinclusions, and variable lipidization.
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