nuclear pore complex


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nuclear pore complex

a nuclear pore and its approximately 50 associated proteins that regulate the transport of materials between the nucleus and the cytoplasm. Composed of cytoplasmic fibrils, cytoplasmic ring, central framework (middle ring), nuclear ring, nuclear basket, and distal ring; a molecular mass of ~125,000 mD. It has an eightfold symmetry and is anchored to the nuclear envelope by nuclear lamina.
Farlex Partner Medical Dictionary © Farlex 2012

nuclear pore complex

A collection of membrane-associated proteins that regulate the passage of large molecules between the cytoplasm and the cell nucleus.
See also: complex
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
(2005) Importin-[alpha] promotes passage through the nuclear pore complex of human immunodeficiency virus type 1 Vpr.
(2017) Karyopherins regulate nuclear pore complex barrier and transport function.
Abbreviations: NPC: nuclear pore complex; SV40: simian virus 40; NLS: nuclear localization signal; cNLS: classical nuclear localization signal; NTR: nuclear transport receptor; Nup: nucleoporin; FG repeat: phenylalanine-glycine repeat; PTAC: nuclear pore-targeting complex; KPNA: karyopherin a; KPNB: karyopherin [beta]; IBB: importin [beta]-binding; Arm: armadillo.
Rome still holds that vaults move about the cytoplasm, periodically docking at nuclear pore complexes to pick up strands of mRNA for transport.