nuclear hormone receptor

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nuclear hormone receptor

member of large family of intracellular molecules that act as ligand-activated transcription factors; all steroid and thyroid hormones and retinoic acid exert their effects through nuclear receptors. Member molecules that have no known ligand have been called orphan nuclear receptor.


A gene (DSS-AHC critical region on the X chromosome, gene 1—formally known, per HUGO nomenclature, as NR0B1) located on chromosome Xp21.3 that encodes a protein containing a DNA-binding domain, which acts as a dominant-negative regulator of transcription mediated by the retinoic acid receptor. DAX1 also acts as an anti-testis gene by antagonising SRY.

Molecular pathology
DAX1 mutations cause both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
References in periodicals archive ?
5] M), we judged the PBDEs and their metabolites to be positive for agonistic or antagonistic activity against that nuclear hormone receptor.
The research in Chapter 7 describes gene expression changes in both in vivo and in vitro rat liver cells treated with nuclear hormone receptor ligands.
Binding of a peroxisome proliferator (ligand) to PPAR[Alpha] activates this nuclear hormone receptor.
New screening methods for chemicals with hormonal activities using interaction of nuclear hormone receptor with coactivator.
antagonists called Selective Estrogen Receptor Covalent Antagonists (SERCAs) that inactivate the estrogen receptor by targeting a cysteine that is not present in other nuclear hormone receptors.
Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response.

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