nuclear factor-kappaB

nuclear factor-κB

an evolutionarily conserved eukaryotic transcription factor system that contributes to the mounting of an effective immune response but also plays an important role in many other cellular processes. NF-κB and its regulators are linked to signal transduction pathways as well as transcriptional activation events that mediate critical stages of cell proliferation, development, and apoptosis.

nu·cle·ar fac·tor-κB

(nū'klē-ăr fak'tŏr)
A transcription factor associated with cytokine production.
References in periodicals archive ?
Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats.
By blocking the inflammatory master molecule nuclear factor-kappaB (or NF-kB), curcumin blunts cancer-causing inflammation, slashing levels of inflammatory cytokines throughout the body.
In recent years, some reports have been published about the use of denosumab, a human monoclonal antibody to receptor activator of nuclear factor-kappaB ligand, for the treatment of FD.
Tumor necrosis factor-alpha induces MMP-9 expression via p42/p44 MAPK, JNK, and nuclear factor-kappaB in A549 cells.
Receptor for advanced glycation end product (RAGE)-mediated nuclear factor-kappaB activation in vasculitic neuropathy.
Atorvastatin decreases C-reactive protein-induced inflammatory response in pulmonary artery smooth muscle cells by inhibiting nuclear factor-kappaB pathway.
Chronic unpredictable stress exacerbates lipopolysaccharide-induced activation of nuclear factor-kappaB in the frontal cortex and hippocampus via glucocorticoid secretion.
Thus, participants who were in the active treatment arm of the original study will receive denosumab for a total of 10 years, whereas patients who crossed over to denosumab after 3 years on placebo will be on the novel RANKL (receptor-activated nuclear factor-kappaB ligand) inhibitor for 7 years.
Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior.
The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis.
And angiotensin-1 and angiotensin-2 expression appears to promote receptor-activated nuclear factor-kappaB ligand activity, which enhances bone loss.

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