novobiocin


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novobiocin

 [no″vo-bi´o-sin]
an antibacterial produced by Streptomyces niveus, used in the treatment of infections caused by staphylococci and other gram-positive organisms. It should be kept in reserve to be used only when necessary, that is, when resistance to other agents has developed. It is effective against infections caused by penicillin-resistant microorganisms, but organisms have been able to develop resistance to novobiocin rapidly. Leukopenia in some patients and jaundice in infants have been observed after novobiocin administration.

novobiocin

(nō′və-bī′ə-sĭn)
n.
An antibiotic, C31H36N2O11, produced by the actinomycete Streptomyces nivens, used primarily in research and to treat infections by gram-positive bacteria in certain animals.

novobiocin

An antibiotic drug formerly of importance in the treatment of infections with staphylococci resistant to other antibiotics but now largely replaced by beta-lactamase resistant penicillins.

novobiocin

an antibacterial produced by Streptomyces niveus, used in the treatment of infections caused by staphylococci and other gram-positive organisms. Called also albamycin, cathomycin.
References in periodicals archive ?
In addition, Kaempherol and novobiocin are the acceptor molec ules with molecular weights of 286 and 612 g/mole, respectively.
The antibiotic sensitivity of isolates was determined against nine antibiotics (norfloxacin 10 ug, streptomycin 10 ug, gentamycin 10 ug, erythromycin 10 ug, chloramphenicol 30 ug, amoxicillin 10 ug, penicillin 10 ug, novobiocin 30 ug, tetracycline 30 ug) by standard method of Kirby and Bauer on Muller Hinton agar (Bauer et al.
The susceptibility of the isolates was determined against 13 antibacterial agents, included: Cefamandol, Cefotaxime, Cloxacillin, Azithromycin, Ampicillin, Ciprofloxacin, Penicillin G, Cephalexin, Colistin, Clindamycin ,mecillinam, tetracycline and Novobiocin.
210420, Becton Dickinson, Sparks, Maryland, USA) and streaked on xylose lactose differential agar plate containing novobiocin 25 pg/mL and nalidixic acid 20 pg/mL.
Organism identification was confirmed with duplicate spots on a Bruker MALDI-TOF (Science Directions Limited, New Zealand) as well as novobiocin resistance by disk diffusion.
coli 0157:H7, meat samples were homogenized using a stomacher and enriched overnight in Modified EC media with novobiocin.
Para realizacao do isolamento da bacteria das fezes ou do solo, devem ser utilizados meios seletivos como o NANAT (nalidixic acid novobiocin actidione-cycloheximide potassium telurite) ou o CAZ-NB (agar ceftazidima-novobiocina), ja que ambos contem antimicrobianos que inibem contaminantes e favorecem a selecao do R.
The antibiotic disc using Streptomycin (10[micro]g/disc), Rifampicin (30[micro]g/disc), Ampicillin (10[micro]g/disc), Carbencilin (100[micro]g/disc), Chloramphenicol (100[micro]g/disc), Novobiocin (30[micro]g/disc), Polymyxin B (300[micro]g/disc), Tetracycline (30[micro]g/disc), Penicillin (30[micro]g/disc), Erythromycin (15[micro]g/disc).
22) Likewise, there is no cleavage of PARP in the presence of novobiocin.
KGG32; NA - Nalidixic acid (30 ug/disc); NV - Novobiocin (30 ug/disc); AMP - Ampicillin (10 ug/disc); P - Penicillin G (10 i.
It includes the company' s inhibitor-free Buffered Peptone Water, which supports the recovery of sublethally damaged organisms prior to further enrichment in media such as Rappaport Vassiliadis Broth, Mueller Kaufmann Tetrathionate Novobiocin Broth (MKTTn) and Selenite Broth.