novobiocin


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novobiocin

 [no″vo-bi´o-sin]
an antibacterial produced by Streptomyces niveus, used in the treatment of infections caused by staphylococci and other gram-positive organisms. It should be kept in reserve to be used only when necessary, that is, when resistance to other agents has developed. It is effective against infections caused by penicillin-resistant microorganisms, but organisms have been able to develop resistance to novobiocin rapidly. Leukopenia in some patients and jaundice in infants have been observed after novobiocin administration.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

novobiocin

(nō′və-bī′ə-sĭn)
n.
An antibiotic, C31H36N2O11, produced by the actinomycete Streptomyces nivens, used primarily in research and to treat infections by gram-positive bacteria in certain animals.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

novobiocin

An antibiotic drug formerly of importance in the treatment of infections with staphylococci resistant to other antibiotics but now largely replaced by beta-lactamase resistant penicillins.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Ten L 1 mM UDP-glucose, 10 L 1mM novobiocin and 10 L enzyme were added into a sterile eppendorf tube and incubated over night at 37C.
For selective enrichment, Lab M's Mueller Kaufmann Tetrathionate Novobiocin Broth (MKTTn) is formulated to inhibit the growth of Proteus species and allow Salmonellae to thrive.
For selective enrichment, proprietary Mueller Kaufmann Tetrathionate Novobiocin Broth is formulated to inhibit the growth of Proteus species.
aureus isolates were found to be resistant to aztreonam, colistin, mecillinam, metronidazole, polymyxin B and nalidixic acid, but all were found to be sensitive to vancomycin, nitrofurantoin and novobiocin. Moreover, various levels of resistance were recorded for the remaining antibiotics.
The antibiotics used for this test were Amoxyclav, Cephalexin, Ciproflaxacin, Clindamycin, Cloxacillin, Co-Trimaxazole, Erythromycin, Tetracyclin, Ampicillin, Carbenicilllin, Cephatoxamine, Chloramphenicol, Co-Trimazine, Gentamicin, Norflaxacin, Oxacillin, Amikacin, Bacitracin, Novobiocin, Vancomycin, Penicillin-G, Tobramycin, Cephaloridine, Kanamycin, Linomycin, Methicillin, Oleandomycin, Nalidixic acid, Sulphamethoxazole, Cefactor, Cefixime, Piperacillin and Cefoperazone.
Substrates of this pump include [beta]-lactams, [beta]-lactamase inhibitors, quinolones, macrolides, tetracyclines, chloramphenicol, novobiocin, sulfonamides, trimethoprim and thiolactomycin (9).
(6) Staphylococcus aureus infections that colonize catheters and other indwelling medical devices were treated with the antibiotic novobiocin until drug-resistant S.
Additional biochemical tests those are useful in separating the Staphylococcus species include catalase, coagulase, growth and fermentation of mannitol salt, andresistance or susceptibility to the antibiotic novobiocin. They were chosen for their high frequencies of food contamination and for their pathogenicites.
Briefly, 4-5 loopful of stool sample was added to 10 ml of modified tryptic soy broth (TSB containing 20 mg/l novobiocin) for enrichment culture and incubated for 6-8 h at 37[degrees]C.
From each BPW tube, 0.1 mL was inoculated into 10mL of RV broth (Oxoid CM 669 containing Novobiocin 35 mg/L) and incubated for 16-24h at 42[degrees]C.
mallei is usually sensitive to a variety of antibiotics including tetracyclines, ciprofloxacin, streptomycin, novobiocin, gentamicin, imipenem, ceftrazidime, and the sulfonamides.