Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
an antibacterial produced by Streptomyces niveus, used in the treatment of infections caused by staphylococci and other gram-positive organisms. It should be kept in reserve to be used only when necessary, that is, when resistance to other agents has developed. It is effective against infections caused by penicillin-resistant microorganisms, but organisms have been able to develop resistance to novobiocin rapidly. Leukopenia in some patients and jaundice in infants have been observed after novobiocin administration.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
An antibiotic, C31H36N2O11, produced by the actinomycete Streptomyces nivens, used primarily in research and to treat infections by gram-positive bacteria in certain animals.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
novobiocinAn antibiotic drug formerly of importance in the treatment of infections with staphylococci resistant to other antibiotics but now largely replaced by beta-lactamase resistant penicillins.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005