atypical antipsychotic

(redirected from novel antipsychotic)

atypical antipsychotic

A dibenzepine-type antipsychotic which differs from conventional antipsychotics in its paucity of extrapyramidal effects (tremor, muscle stiffness and restlessness).
 
Adverse effects
Insomnia, anxiety, agitation, sedation, dizziness, rhinitis, orthostatic hypotension, tachycardia, weight gain, menstrual disturbances, seizures; rarely, severe granulocytopaenia or agranulocytosis; should not be used in patients with liver, brain or circulatory defects.
 
Examples
Clozapine (Clozaril), ziprasidone (Geodon), loxapine (Loxitane), olanzapine (Zyprexa), resperidone (Risperdal), quetiapine (Seroquel).

antipsychotic

(ant?i-si?kot'ik) [ anti- + psychotic]
1. Preventing or treating psychosis, e.g., schizophrenia.
2. A medication to treat psychosis.

atypical antipsychotic

Second-generation antipsychotic.

first-generation antipsychotic

A neuroleptic drug. They treat psychotic disorders and other psychiatric diseases. Side effects include extrapyramidal (Parkinsonian) reactions. Synonym: conventional antipsychotic See: neuroleptic (1)

conventional antipsychotic

First-generation antipsychotic.

second-generation antipsychotic

An antipsychotic drug that causes increased appetite, weight gain, and adverse effects on lipids. They differ from first-generation antipsychotics in that they are less likely to cause extrapyramidal side effects or tardive dyskinesia.
Synonym: atypical antipsychotic
References in periodicals archive ?
Release date- 25072019 - London - Hikma Pharmaceuticals PLC (Hikma, Group) (LSE: HIK) (NASDAQ Dubai: HIK) (OTC: HKMPY) (rated Ba1 Moody's / BB+ S&P, both stable), the multinational pharmaceutical company, and Gedeon Richter PLC (Richter) today announced the signing of an exclusive license agreement to commercialise cariprazine, a novel antipsychotic, in certain Middle East and North African (MENA) markets.
Functional characterization of the novel antipsychotic iloperidone at human D2, D3, alpha 2C, 5-HT6, and 5-HT1A receptors.
Novel antipsychotic medications show significantly less dopamine antagonism and exert their clinical effects through their actions on the serotonin, histamine and norepinephrine pathways.
Key clinical point: The novel antipsychotic ITI-007 met its primary endpoint in a phase II trial and showed good tolerability and safety.
Y., Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain, Eur J Pharmacol., 2004; 493:75-83
Minamida et al., "Syntheses and properties of the major hydroxy metabolites in humans of blonanserin AD-5423, a novel antipsychotic agent," Bioorganic and Medicinal Chemistry Letters, vol.
Risperidone is a novel antipsychotic that shows a high affinity with 5[HT.sub.2A], 5[H.sub.T7] , [[alpha].sub.1], [H.sub.1], [D.sub.2], [[alpha].sub.2], and 5[HT.sub.2D] receptors, and although it belongs to atypical agents, it has been found to exceed in hyperprolactinaemia compared to conventional antipsychotic drugs [45].
Pharmaceutical company Cypress Bioscience Inc (NASDAQ:CYPB) revealed on Tuesday the receipt of written notice of consent and effectiveness for BioLineRx's novel antipsychotic, BL-1020 (now CYP-1020), as part of a previous in-license agreement between the two companies.
Risperidone is a novel antipsychotic and the only drug that has received Food and Drug Administration approval, for any reason, for symptoms associated with autism.
More studies are needed to define the therapeutic window of this novel antipsychotic drug.

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