atypical antipsychotic

(redirected from novel antipsychotic)

atypical antipsychotic

A dibenzepine-type antipsychotic which differs from conventional antipsychotics in its paucity of extrapyramidal effects (tremor, muscle stiffness and restlessness).
 
Adverse effects
Insomnia, anxiety, agitation, sedation, dizziness, rhinitis, orthostatic hypotension, tachycardia, weight gain, menstrual disturbances, seizures; rarely, severe granulocytopaenia or agranulocytosis; should not be used in patients with liver, brain or circulatory defects.
 
Examples
Clozapine (Clozaril), ziprasidone (Geodon), loxapine (Loxitane), olanzapine (Zyprexa), resperidone (Risperdal), quetiapine (Seroquel).

antipsychotic

(ant?i-si?kot'ik) [ anti- + psychotic]
1. Preventing or treating psychosis, e.g., schizophrenia.
2. A medication to treat psychosis.

atypical antipsychotic

Second-generation antipsychotic.

first-generation antipsychotic

A neuroleptic drug. They treat psychotic disorders and other psychiatric diseases. Side effects include extrapyramidal (Parkinsonian) reactions. Synonym: conventional antipsychotic See: neuroleptic (1)

conventional antipsychotic

First-generation antipsychotic.

second-generation antipsychotic

An antipsychotic drug that causes increased appetite, weight gain, and adverse effects on lipids. They differ from first-generation antipsychotics in that they are less likely to cause extrapyramidal side effects or tardive dyskinesia.
Synonym: atypical antipsychotic
References in periodicals archive ?
Novel antipsychotic medications show significantly less dopamine antagonism and exert their clinical effects through their actions on the serotonin, histamine and norepinephrine pathways.
Comparison of long-acting injectable risperidone and oral novel antipsychotic drugs for treatment in early phase of schizophrenia spectrum psychosis.
Key clinical point: The novel antipsychotic ITI-007 met its primary endpoint in a phase II trial and showed good tolerability and safety.
Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain, Eur J Pharmacol.
Pharmaceutical company Cypress Bioscience Inc (NASDAQ:CYPB) revealed on Tuesday the receipt of written notice of consent and effectiveness for BioLineRx's novel antipsychotic, BL-1020 (now CYP-1020), as part of a previous in-license agreement between the two companies.
Risperidone is a novel antipsychotic and the only drug that has received Food and Drug Administration approval, for any reason, for symptoms associated with autism.
More studies are needed to define the therapeutic window of this novel antipsychotic drug.
Pharmacokinetics of the novel antipsychotic agent risperidone and prolactin response in healthy subjects, Clin Pharmacol Ther 1993;54(3)257-67.
Ziprasidone, a novel antipsychotic, may be effective in diminishing motor and vocal tics in children and adolescents with Tourette's syndrome or chronic tic disorder, said Dr.
Sexual side effects of novel antipsychotic medications.
Functional characterization of the novel antipsychotic iloperidone at human [D.

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