notum


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Related to notum: tergum

notum

(nō′təm)
n. pl. no·ta (-tə)
The dorsal part of a thoracic segment of an insect.
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References in periodicals archive ?
The study shows that during aging, Paneth cells begin to express the secreted Wnt-inhibitor Notum, which enzymatically inactivates Wnt-ligands in the stem cell niche, decreasing regenerative potential of intestinal stem cells.
However, pharmacologic inhibition of Notum rejuvenated stem cell activity and promoted the recovery of old animals after treatment with a commonly used chemotherapeutic drug with severe side-effects in the gut.
Citation: Nalle Pentinmikko et al., Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.