They usually arise from embryonic notochordal
remnants along the length of the neuraxis at developmental active sites represented by the ends of the neuraxis and the vertebral bodies.
Woo, "The apoptotic effects of oxidative stress and antiapoptotic effects of caspase inhibitors on rat notochordal
cells," Spine, vol.
Chordomas are rare, slow-growing malignant yet locally aggressive osteolytic primary bone tumours derived from persistent notochordal
remnants that principally arise in the axial skeleton.1,2 Cases of extra-axial chordomas have also been reported.3 They make up about 1% of all intracranial, 4% of primary bone and 2% of spinal tumours4,5 They are the most common primary bone tumours of spine and have a male to female ratio of 2:1.
The origin of chondrocytes in the nucleus pulposus and histologic findings associated with the transition of a notochordal
nucleus pulposus to a fibrocartilaginous nucleus pulposus in intact rabbit intervertebral discs.
When Shh is synthesized by the notochordal
cells, it not only controls cell fate of neurons in the neural tube, ventral location so that they can be identified as motor neurons, but also participates in determining the sclerotome and pattern formation of somites (Bumcrot & McMahon, 1995; Munsterberg & Lassar, 2005; Lassar & Munsterberg, 1996).
Persistence of canal on basilar part of clivus is a rare congenital defect of skull base representing an embryological remnant depicting the cephalic end of the notochord and corresponds to the course of the notochordal
canal in the basiocciput caudally.
At present at least 3 different NP cell types "chondrocytelike" cells (NP), notochordal
cells (NCs) and NP stem/ progenitor cells (NPPCs), have been identified within the NP.
Several in vivo studies have used notochordal
nucleus pulposus (NP) cells, autologous disc chondrocytes, and mesenchymal stromal cells (MSC) to generate new disc formation.
Chordomas are rare, slow-growing tumours that originate from ectopic notochordal
remnants, found along the axial skeleton.
cell tumors: A comparative histological study of benign notochordal
cell tumors, classic chordomas, and notochordal
vestiges of fetal intervetebral discs.