noscapine


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noscapine

 [nos´kah-pēn]
an alkaloid present in opium; used as a nonaddictive antitussive.

nos·ca·pine

(nos'kă-pēn),
An isoquinoline alkaloid, occurring in opium, with papaverinelike action on smooth muscle; suppresses the cough reflex and this is used as an antitussive; it does not appear to cause addiction.
Synonym(s): l-α-narcotine, opianine

noscapine

(nŏs′kə-pēn′)
n.
A nonnarcotic alkaloid obtained from the opium poppy, C22H23NO7, that has antitussive and antitumor properties and has been used as a cough suppressant.
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References in periodicals archive ?
Cinchonidine (1), cinchonine (2), quinine (3), and noscapine (narcotine, 4) are the alkaloids which are used for the treatment of biological diseases like malaria, analgesic pain, anti-inflammatory, cancer, and stroke treatment [5].
Mirahmadi Zare, "Modified glassy carbon electrode with multiwall carbon nanotubes as a voltammetric sensor for determination of noscapine in biological and pharmaceutical samples," Sensors and Actuators B, vol.
The study shows that noscapine inhibited tumor growth in mice and also limited the spread of tumors without causing any side effects.
Based on ASTHPHYLLIN, the company's proprietary ethical drug indicated for asthma, the new product contains diprophylline, dl-methylephedrine hydrochloride, noscapine, and diphenhydramine hydrochloride, and helps alleviate coughing and loosen phlegm.
Drug name Therapeutic category Acetaminophen Analgesic; antipyretic Ambroxol Expectorant Bromhexine Expectorant; mucolytic Caffeine CNS stimulant; respiratory stimulant Carbinoxamine Antihistaminic d-Chlorpheniramine Antihistaminic Clemastine Antihistaminic Dextromethorphan Antitussive Dihydrocodeine Analgesic (narcotic); antitussive Ethenzamide Analgesic Guaiacol Expectorant Guaifenesin Expectorant Ibuprofen Anti-inflammatory; analgesic; antipyretic Isopropamide Antispasmodic Loxoprofen (R, S) Anti-inflammatory; analgesic Mequitazine Antihistaminic d-Methylephedrine Analeptic Noscapine Antitussive Pseudoephedrine Decongestant Tranexamic acid Hemostatic TABLE 2: Binding affinities of the ingredients of cold medicines to the antigenic-peptide binding groove of HLA-A * 02:06.
(3) (a) OP, opioids; AMP, amphetamines; COC, cocaine; BENZO, benzodiazepines; F, fortified; T, treatment; D, DUID; DAD, diode array detection; E, experimental; s, synthetic OF; PV, papaverine; NC, noscapine; pOHBE, p-hydroxybenzoylecgonine.
The opium poppy is the type of poppy from which opium and many refined opiates, including heroin, morphine, thebaine, codeine, papaverine and noscapine, are extracted.
The collaborative study revealed that noscapine, which has been used in cough medication for nearly 50 years, reduced tumour growth in mice by 60 percent and limited the spread of tumours by 65 percent without causing harmful side effects.
These medications usually consist of a combination of antipyretic analgesics (e.g., acetaminophen or ibuprofen), antitussives (e.g., dihydrocodeine phosphate or noscapine), expectorants (e.g., bromohexine hydrochloride, guaifenesin, or potassium guaiacolsulfonate), exogenous enzyme (e.g., lysozyme chloride), bronchodilator (e.g., dl-methylephedrine hydrochloride), antihistaminics (e.g., carbinoxamine maleate or mequitazine), vitamins (e.g., vitamin B1, B2, or vitamin C), and others (e.g., herbal medicines or caffeine).
Noscapine, a cough suppressant long used in South Africa, Japan, and Sweden, may someday help combat a much more serious ailment--cancer.