noscapine


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noscapine

 [nos´kah-pēn]
an alkaloid present in opium; used as a nonaddictive antitussive.

nos·ca·pine

(nos'kă-pēn),
An isoquinoline alkaloid, occurring in opium, with papaverinelike action on smooth muscle; suppresses the cough reflex and this is used as an antitussive; it does not appear to cause addiction.
Synonym(s): l-α-narcotine, opianine

noscapine

(nŏs′kə-pēn′)
n.
A nonnarcotic alkaloid obtained from the opium poppy, C22H23NO7, that has antitussive and antitumor properties and has been used as a cough suppressant.

noscapine

an alkaloid present in opium; used as a nonaddictive antitussive.
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References in periodicals archive ?
Cinchonidine (1), cinchonine (2), quinine (3), and noscapine (narcotine, 4) are the alkaloids which are used for the treatment of biological diseases like malaria, analgesic pain, anti-inflammatory, cancer, and stroke treatment [5].
They concluded that noscapine administered as a preventive measure may offer significant benefits in the management of prostate cancer.
Their findings said: "Pre-treatment with noscapine confers a significant benefit compared with control in both primary tumor growth and primary tumor growth- inhibition rate and exhibits an extremely favorable tolerability profile.
Noscapine has previously been studied as a treatment for breast, ovarian, colon, lung and brain cancer and for various lymphomas, chronic lymphocytic leukemia and melanoma.
Noscapine is a naturally-occurring substance, a non-addictive derivative of opium.
17 Proceedings of the National Academy of Sciences, believe that noscapine exerts its anticancer effects by binding tubulin, a protein that forms the cellular filaments called microtubules.
When the investigators gave noscapine to mice with solid tumors, including animals implanted with human breast or bladder tumors, the drug dramatically shrank the cancers.