Anesthesia techniques, such as hypotensive anesthesia and normovolemic
hemodilution, have both been shown to be effective in decreasing postoperative ABT requirements but can be challenging logistically.
A moderate number of surgeons reported using procedural hemostatic techniques, such as CellSaver (8; 31%), autologous blood banking (4; 15%), or acute normovolemic
hemodilution (10; 26%) (Table 3).
Continuous Noninvasive Hemoglobin Monitoring for Jehovah's Witness Patients Undergoing Intraoperative Autologous Normovolemic
Hemodilution" ASA 2011 Presentation A408.
27,28) Likewise, in two small prospective studies (n = 7 and 8, respectively) involving coronary artery bypass graft patients without religious objections to transfusion, normovolemic
hemodilution to a hematocrit of l5% was well tolerated during surgery, (29) without evidence of myocardial ischemia on electrocardiogram and without affecting either lactate extraction or hypoxanthine release.
Value of the association of normovolemic
dilution and hyperbaric oxygenation in the treatment of sudden deafness.
The two clinical applications that seem most likely to be approved are for patients with acute trauma, where several blood volumes of HBOCs have been infused without complications, and in acute normovolemic
hemodilution protocols, where the HBOC permits aggressive lowering of the patient's red cells for re-infusion after surgery.
In some operations, a procedure called acute normovolemic
hemodilution, is performed to avoid exposing the patient to allogeneic blood (donated by other people).
She was maintained in a normovolemic
state as per our SAH protocol.
Erythropoietin and blood substitutes work best when combined with a technique called acute normovolemic
This includes measures such as autologous donations before elective surgery, the use of cell savers, reinfusion of shed blood, "and the realization that in many patients normovolemic
anemia is not life-threatening.
Pharmacokinetics from multiple intraosseous and peripheral intravenous site injections in normovolemic
and hypovolemic pigs.
hemodilution or intra-operative autologous donation), which were implicated in safety issues in a previous Alliance Phase 3 clinical trial.