Damm et al used magnetic resonance imaging to assess intranasal volume and its relationship to olfactory function in normosmic
idiopathic hypogonadotropic hypogonadism due to novel homozygous nonsense c.
Parkinson disease a unique clinical phenotype?
This retrospective study was done by reviewing the medical records of 91 IHH (including 62 normosmic IHH and 29 Kallmann syndrome) and 27 CDP patients, who presented at Chinese PLA General Hospital between 1994 and 2011, as well as 6 normal prepubertal children, and 20 normal pubertal volunteers.
Normosmic idiopathic hypogonadotropic hypogonadism : Update on the genetic background and future challenges.
Of the 203 hyposmic subjects, 11% had a DAT level less than 65%, compared with 1 % of the normosmic group, a significant difference.
Indeterminate DAT levels were seen in 17% of the hyposmic and in 7% of the normosmic groups, and normal levels were seen in 71% of the hyposmic and 92% of the normosmic groups.
Of the 203 hyposmic subjects, 11% had a DAT level less than 65%, compared with 1% of the normosmic group, a significant difference.
Major Finding: Significantly more individuals with hyposmia had DAT levels of 65% or lower, compared with normosmic individuals (11% vs.
No patients in a control cohort among the relatives who were normosmic
at baseline went on the develop the disease, and the study concluded that idiopathic olfactory dysfunction in family members of Parkinson's disease patients is associated with at least a 10% increased risk of developing the disease (Ann.
These 3 patients included 1 in the sinonasal category who improved from hyposmic to normosmic
, 1 in the post-URTI category who improved from anosmic to hyposmic, and 1 in the post-traumatic category who remained anosmic.
A relatively recent development has enabled researchers to obtain nasal (trigeminal) irritant thresholds using odorous volatile organic compounds (VOCs) among normosmic