These 3 patients included 1 in the sinonasal category who improved from hyposmic to normosmic, 1 in the post-URTI category who improved from anosmic to hyposmic, and 1 in the post-traumatic category who remained anosmic.
l%)--experienced a clinically relevant improvement at 4 months; 1 patient in the post-URTI category improved from hyposmic to normosmic, and 1 patient in the idiopathic category improved from anosmic to hyposmic.
Of the 203 hyposmic subjects, 11% had a DAT level less than 65%, compared with 1 % of the normosmic group, a significant difference.
Indeterminate DAT levels were seen in 17% of the hyposmic and in 7% of the normosmic groups, and normal levels were seen in 71% of the hyposmic and 92% of the normosmic groups.
No patients in a control cohort among the relatives who were normosmic
at baseline went on the develop the disease, and the study concluded that idiopathic olfactory dysfunction in family members of Parkinson's disease patients is associated with at least a 10% increased risk of developing the disease (Ann.
A relatively recent development has enabled researchers to obtain nasal (trigeminal) irritant thresholds using odorous volatile organic compounds (VOCs) among normosmic