Neither normocholesterolemia nor hypercholesterolemia showed sexual difference in migratory activity or proliferative activity of EPCs.
The results showed decreased amount and activity of circulating EPCs, as well as FMD, in postmenopausal hypercholesterolemic patients versus subjects with normocholesterolemia. It indicated that hypercholesterolemia could decrease EPC number and impair EPC function and further led to endothelial dysfunction.
Serum levels of cholesterol and LDL-cholesterol were 308.7[+ or -]142.4, 243.7[+ or -]146.7 mg/dL in subjects with hypercholesterolemia, and 154.2[+ or -]17.3 and 86.8[+ or -]17.5 in those with normocholesterolemia
. These differences between the two groups were significant (p<0.001).
As per the subject's total cholesterol results, 2 groups were made as Normocholesterolemia
(Total cholesterol Less than 5.2 mmol/L) and Hypercholesterolemia (Total cholesterol Greater than 5.1 mmol/L).
Agreement with BQ was reasonable in specimens from individuals with normocholesterolemia
, combined hyperlipidemia, or isolated hypoalphalipoproteinemia (94); in contrast, hypercholesterolemia produced a negative bias (-5.8%).