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A metabolite of meperidine in which the N-methyl group has been removed. The compound possesses convulsant properties.
References in periodicals archive ?
Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure or cancer.
Normeperidine, which is a toxic metabolite of Demerol, acts as a cerebral irritant and may cause dysphoria, mood changes, hallucinations, and seizures.
25] Meperidine is metabolized by the liver into the toxic metabolite, normeperidine, which is a cerebral irritant that has nervous system stimulating effects including dysphoria, irritable mood swings and seizures.
Although there are no active metabolites for acetaminophen, salicylic acid, or ibuprofen (17), meperidine and propoxyphene are hepatically metabolized to the toxic substances normeperidine and norpropoxyphene/dinorpropoxyphene, respectively.
The patient on repeated doses of meperidine, particularly if orally administered, must be monitored closely for the onset of tremors, myoclonic jerking, or seizures indicative of normeperidine accumulation.
Meperidine is broken down into a long-acting toxic metabolite - normeperidine - which has little analgesic activity and can cause central nervous system excitation, mood changes, and seizures (Morrison, 1991 Steingart, 1992).