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A metabolite of meperidine in which the N-methyl group has been removed. The compound possesses convulsant properties.
References in periodicals archive ?
Normeperidine is an active nonopioid metabolite that is clinically important in that it is not naloxone-reversible.
25] Meperidine is metabolized by the liver into the toxic metabolite, normeperidine, which is a cerebral irritant that has nervous system stimulating effects including dysphoria, irritable mood swings and seizures.
Although there are no active metabolites for acetaminophen, salicylic acid, or ibuprofen (17), meperidine and propoxyphene are hepatically metabolized to the toxic substances normeperidine and norpropoxyphene/dinorpropoxyphene, respectively.