normeperidine


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nor·me·per·i·dine

(nōr'me-per'i-dēn),
A metabolite of meperidine in which the N-methyl group has been removed. The compound possesses convulsant properties.
References in periodicals archive ?
Agent Drawback Morphine Meperidine Normeperidine quickly accumulates, elicits side effects.
Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure or cancer.
Normeperidine, which is a toxic metabolite of Demerol, acts as a cerebral irritant and may cause dysphoria, mood changes, hallucinations, and seizures.
Only 1% of UK neuroanaesthetists report using IM meperidine as their first-line postoperative analgesia for craniotomy patients.[25] Meperidine is metabolized by the liver into the toxic metabolite, normeperidine, which is a cerebral irritant that has nervous system stimulating effects including dysphoria, irritable mood swings and seizures.[1,5] Meperidine should therefore be used with caution the neurosurgical patient population.
Although there are no active metabolites for acetaminophen, salicylic acid, or ibuprofen (17), meperidine and propoxyphene are hepatically metabolized to the toxic substances normeperidine and norpropoxyphene/dinorpropoxyphene, respectively.
Meperidine is broken down into a long-acting toxic metabolite - normeperidine - which has little analgesic activity and can cause central nervous system excitation, mood changes, and seizures (Morrison, 1991 Steingart, 1992).