Comparison of the deep optic nerve head structure between normal-tension glaucoma
and nonarteritic anterior ischemic optic neuropathy.
3,4,6) It has been shown that with lower IOP and in cases of normal-tension glaucoma
(NTG), there is less incidence of SVP and a greater pressure needs to be applied to the globe in order to induce SVP; this equates to a greater difference in IOP and CRV pressure and implies that local vessel haemodynamics are involved in the glaucoma process.
Some people have low-tension or normal-tension glaucoma
, where optic nerve damage occurs even when the IOP is in the normal range (12-22 millimeters of mercury).
Correlation of age and intraocular pressure with visual field damage in patients with normal-tension glaucoma
7] Nitta E, Hirooka K, Tenkumo K, Fujita T, Nishiyama A, Nakamura T, et al Aldosterone: A mediator of retinal ganglion cell death and the potential role in the pathogenesis in normal-tension glaucoma
In fact, probucol protects against glutamate-induced cytotoxicity in a neuronal cell line  and, intriguingly, glutamate toxicity is one of the main pathogenic mechanisms of normal-tension glaucoma
Association between nocturnal blood pressure reduction and progression of visual field defect in patients with primary open-angle glaucoma or normal-tension glaucoma
Fluctuations of intraocular pressure during the day in open-angle glaucoma, normal-tension glaucoma
and normal subjects.
Research under way reveals that loss of vision in normal-tension glaucoma
in particular is due to both intraocular pressure and low blood flow.
Ahn, "Analysis of systemic endothelin-1, matrix metalloproteinase-9, macrophage chemoattractant protein-1, and high-sensitivity C-reactive protein in normal-tension glaucoma
," Current Eye Research, vol.
However, some people have normal-tension glaucoma
, in which the eye pressure remains in the normal range despite damage to the optic nerve.
Eisengart notes that about one-third of his glaucoma patients have normal-tension glaucoma
, in which the optic nerve suffers damage even though eye pressure remains in the normal range (10-21 mmHg).