nordoxepin

nordoxepin

See Doxepin.
References in periodicals archive ?
This medication is metabolized by demethylation and oxidation; the primary metabolite is nordoxepin (N-desmethyldoxepin), which later undergoes glucuronide conjugation.
Other drugs assayed at therapeutic concentrations that had no interference included carbamazepine and its epoxide and hydroxy metabolites, oxcarbazepine and it monohydroxylated metabolite, zonisamide, levetiracetam, phenytoin and its metabolites, felbamate, lamotrigine, clonazepam, phenobarbital, primidone, acetaminophen, salicylate, ibuprofen, amitriptyline, nortriptyline, desipramine, doxepin and nordoxepin, imipramine, valproic acid, topiramate, mephenytoin and Nirvanol, amiodarone and desethylamiodarone, methsuximide and normethsuximide, ethotoin, clozapine, and sertraline.
In several cases, the following substances were detectable only after cleavage of conjugates: oxazepam, temazepam, lormetazepam, morphine, codeine, hydroxypromethazine, norhydroxypromethazine, nordoxepin, norhydroxydoxepin, hydroxytrimipramine, viloxazine, or hydroxyviloxazine.