nordihydroguaiaretic acid


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nordihydroguaiaretic acid

A relatively nontoxic phenolic quinone obtained from the oily resin of the evergreen shrub (chaparral) or creosote bush (Larrea divaricata, Covillea tridentata).

Alternative pharmacology
NDGA appears to have a broad spectrum of anticancer properties, the efficacy of which is attributed to NDGA’s antioxidant activity, its virtually complete inhibition of anaerobic glycolysis and its inhibition of DNA synthesis; NDGA may be useful in treating choriocarcinoma, gastrointestinal tumours, gliomas of the brain, leukaemia, lymphoma and melanoma.

nordihydroguaiaretic acid

one of a group of chemicals which cause renal cysts when administered to experimental animals.
References in periodicals archive ?
The effect of nordihydroguaiaretic acid on iodoacetate-induced toxicity in cultured neurons.
Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/H0-1 and protects cerebellar granule neurons against oxidative stress.
The protective effect of nordihydroguaiaretic acid on cerebral ischemia/reperfusion injury is mediated by the JNK pathway.
Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update.
Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability, role of glycogen synthase kinase-3.
Multiple effects of nordihydroguaiaretic acid on ionic currents in rat isolated type I carotid body cells.
current by nordihydroguaiaretic acid in porcine coronary arterial smooth muscle cells.

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