nordihydroguaiaretic acid


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nordihydroguaiaretic acid

A relatively nontoxic phenolic quinone obtained from the oily resin of the evergreen shrub (chaparral) or creosote bush (Larrea divaricata, Covillea tridentata).

Alternative pharmacology
NDGA appears to have a broad spectrum of anticancer properties, the efficacy of which is attributed to NDGA’s antioxidant activity, its virtually complete inhibition of anaerobic glycolysis and its inhibition of DNA synthesis; NDGA may be useful in treating choriocarcinoma, gastrointestinal tumours, gliomas of the brain, leukaemia, lymphoma and melanoma.
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References in periodicals archive ?
Larrea tridentata (Creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid. Journal of Ethnopharmacology 98 (3): 231-239.
Uso potencial de extractos de Larrea divaricata con bajo contenido de NDGA como antioxidantes en comidas
Toxic properties of nordihydroguaiaretic acid. Food and Cosmetics Toxicology 6:155-161.
INTERPOPULATION DIFFERENCES IN TOLERANCE TO CREOSOTE BUSH RESIN IN DESERT WOODRATS (NEOTOMA LEPIDA)
Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/H0-1 and protects cerebellar granule neurons against oxidative stress.
Nordihydroguaiaretic acid induces Nrf2 nuclear translocation in vivo and attenuates renal damage and apoptosis in the ischemia and reperfusion model
Multiple effects of nordihydroguaiaretic acid on ionic currents in rat isolated type I carotid body cells.
Arylnaphthalene lignans from Taiwania cryptomerioides as novel blockers of voltage-gated [K.sup.+] channels
Arachidonic acid (AA), phorbol myristate acetate (PMA), indomethacin, dexamethasone, dimethyl sulfoxide (DMSO), interferon gamma (IFN[gamma]), bacterial lipopolysaccharide (LPS), calcium ionophore A23187, O-dianisidine, nordihydroguaiaretic acid (NDGA), and all other reagents were obtained from Sigma Chemical Co.
Protective effects of a standard extract of Mangifera indica L. (VIMANG[R]) against mouse ear edemas and its inhibition of eicosanoid production in J774 murine macrophages
Nash and will include "Protection of artificial hair color," "Effect of mineral, sunflower and coconut oil on prevention of hair damage," "Ellipticity of body hair and how to measure its apparent diameter," "Photooxidation of human hair--damaging consequences and remediation" and "Exposure considerations relevant to hair dye safety." Finally, Session E, with moderator Linda Rhein, will feature "Synergies in combatting acne-prone skin: oleanic acid and nordihydroguaiaretic acid inhibit 5-alpha reductase," "Cosmeceutical properties of fermented sage compound" and "Post adolescent acue: cosmetic relevance." More info: (212) 668-1500; Fax: (212) 668-1504; Website: www.scconline.org.
SCC announces schedule for annual meeting in NY. (SCC News)
Three LOX inhibitors, the non-specific inhibitor nordihydroguaiaretic acid, the 5-LOX inhibitor Rev-5901 and the 12-LOX inhibitor baicalain were all found to inhibit in vitro and in vivo growth of pancreatic cancer cell lines as well as inducing apoptosis.
Anti-proliferative lichen compounds with inhibitory activity on 12(S)-HETE production in human platelets
Nordihydroguaiaretic acid (SIGMA Chemicals) was used as a positive control.
Effects of tenuiorin and methyl orsellinate from the lichen Peltigera leucophiebia on 5-/15-lipoxygenases and proliferation of malignant cell lines in vitro

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