nordihydroguaiaretic acid


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nordihydroguaiaretic acid

A relatively nontoxic phenolic quinone obtained from the oily resin of the evergreen shrub (chaparral) or creosote bush (Larrea divaricata, Covillea tridentata).

Alternative pharmacology
NDGA appears to have a broad spectrum of anticancer properties, the efficacy of which is attributed to NDGA’s antioxidant activity, its virtually complete inhibition of anaerobic glycolysis and its inhibition of DNA synthesis; NDGA may be useful in treating choriocarcinoma, gastrointestinal tumours, gliomas of the brain, leukaemia, lymphoma and melanoma.
References in periodicals archive ?
Larrea tridentata (Creosote bush), an abundant plant of Mexican and US-American deserts and its metabolite nordihydroguaiaretic acid. Journal of Ethnopharmacology 98 (3): 231-239.
Toxic properties of nordihydroguaiaretic acid. Food and Cosmetics Toxicology 6:155-161.
Nordihydroguaiaretic acid activates the antioxidant pathway Nrf2/H0-1 and protects cerebellar granule neurons against oxidative stress.
Multiple effects of nordihydroguaiaretic acid on ionic currents in rat isolated type I carotid body cells.
Arachidonic acid (AA), phorbol myristate acetate (PMA), indomethacin, dexamethasone, dimethyl sulfoxide (DMSO), interferon gamma (IFN[gamma]), bacterial lipopolysaccharide (LPS), calcium ionophore A23187, O-dianisidine, nordihydroguaiaretic acid (NDGA), and all other reagents were obtained from Sigma Chemical Co.
Nash and will include "Protection of artificial hair color," "Effect of mineral, sunflower and coconut oil on prevention of hair damage," "Ellipticity of body hair and how to measure its apparent diameter," "Photooxidation of human hair--damaging consequences and remediation" and "Exposure considerations relevant to hair dye safety." Finally, Session E, with moderator Linda Rhein, will feature "Synergies in combatting acne-prone skin: oleanic acid and nordihydroguaiaretic acid inhibit 5-alpha reductase," "Cosmeceutical properties of fermented sage compound" and "Post adolescent acue: cosmetic relevance." More info: (212) 668-1500; Fax: (212) 668-1504; Website: www.scconline.org.
Three LOX inhibitors, the non-specific inhibitor nordihydroguaiaretic acid, the 5-LOX inhibitor Rev-5901 and the 12-LOX inhibitor baicalain were all found to inhibit in vitro and in vivo growth of pancreatic cancer cell lines as well as inducing apoptosis.

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