nordiazepam


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Related to nordiazepam: oxazepam, lorazepam, temazepam

nordiazepam

Neuropharmacology A long-acting sedative/hypnotic. See Benzodiazepine.
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The half-life of diazepam and its metabolites (such as nordiazepam) makes it possible to maintain elevated serum levels of active substance, enabling progressive reduction over time (Figure 1) and thereby preventing abstinence symptoms from appearing.
Diazepam and its metabolites nordiazepam and temazepam were measured by LC-MS/MS in 4 independent experiments.
nordiazepam in the hair of drug addicts]; Ann pharm Fr 54:211; 1996.
Reported concentrations ranged from 4 [micro]g/L for temazepam, nordiazepam, or oxazepam to 221 [micro]g/L for nordiazepam in DUID (69).
Solution B contained: 7-aminoflunitrazepam, 7-aminonitrazepam, alprazolam, clonazepam, 7-aminoclonazepam, flunitrazepam, buprenorphine, nordiazepam, and nitrazepam.
For the LC-MS/MS quantification of diazepam, nordiazepam, and oxazepam, the chromatographic peaks were sharp, and no interference from the blood matrix was observed (see Fig.
Blood: HepB (-), HepC (+), HIV (-) (a) Morphine, alcohol, nordiazepam, norpropoxyphene, hydroxyzine, cocaine, chlorpheniramine, propoxyphene, and benzodiazepines.
Because oxazepam and nordiazepam are common metabolites of many benzodiazepines, identification of the corresponding parent compounds was based on MS detection of more specific metabolites or the parent compound itself.
The cutoff concentrations, above which a sample is considered positive, are as follows: morphine, 10 [micro]g/L; n-methamphetamine, 100 [micro]g/L; nordiazepam, 100 [micro]g/L; benzoylecgonine (BE), 150 [micro]g/L; PCP, 10 [micro]g/L; and L-11-nor-9-carboxy-[[Delta].sup.9]-tetrahydrocannabinol (THCA), 30 [micro]g/L.
The extracts were derivatized with methyl-(tert-butyldimethylsilyl)-trifluoroacetamide (Pierce Chemical Co.) for quantification of nordiazepam, oxazepam, temazepam, lorazepam, hydroxyethylflurazepam, [alpha]-hydroxyalprazolam, and [alpha]-hydroxytriazolam.
Detection limit, mg/L Drug UV 254 nm [Cl.sub.2] HCI HgS[O.sub.4] Acetaminophen 0.50 2.5 NR NR Caffeine 0.10 NR NR NR Carbamazepine 0.20 0.02 0.04 NR Carisoprodol NR NR NR 1.0 Nordiazepam 0.10 0.05 0.1 NR Theophylline 0.20 NR NR NR Secobarbital NR NR NR 0.2 NR, no obvious reaction with the reagent indicated.

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