nonsteroidal antiinflammatory drug


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nonsteroidal antiinflammatory drug (NSAID)

[-stir′oidəl]
any of a group of drugs having antipyretic, analgesic, and antiinflammatory effects. They counteract or reduce inflammation by inhibiting cyclooxygenase, the enzyme responsible for prostaglandin synthesis. NSAIDs may be indicated in the treatment of mild-to-moderate pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylosis, gouty arthritis, fever, nonrheumatic inflammation, and dysmenorrhea. Classic examples include aspirin, ibuprofen, and ketoprofen. Newer drugs such as celecoxib, refecoxib, and valdecoxib selectively block only the inductible form of cyclooxygenase (COX-2), the form of the enzyme that appears in cells at sites of inflammation, and tend to have fewer side effects.

non·ste·roi·dal an·ti·in·flam·ma·to·ry drug

(NSAID) ( non'ster-oy'dăl an'tī-in-flam'ă-tŏr-ē drŭg)
Any one of a group of pharmacotherapeutic agents exerting antiinflammatory (and also usually analgesic and antipyretic) actions (e.g., aspirin, diclofenac, ibuprofen, and naproxen). A contrast is made with steroidal compounds (e.g., hydrocortisone or prednisone) exerting antiinflammatory activity.

Patient discussion about nonsteroidal antiinflammatory drug

Q. Is there any good source for heel pain relief, besides NSAIDs? My heel pain is most severe at night when I sleep. It's as if the way I position my feet worsen the condition, but I'm at a loss to know how to position my feet. During the day my heels feel so but don't typically bother me.

A. I have found that keeping my feet flexed (the position they are in when standing) helps ease the pain of plantar facitis. I also don't let my feet get cold(wear socks)and keep heavy blankets and quilts off the feet. Placing a box under the covers at the foot of the bed will help keep the blankets up. Do try the exercises recommended on the above web sites. It usually resolves in about 6 months. Best wishes!

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References in periodicals archive ?
Comparing acetylated salicylates, nonacetylated salicylates, and nonacetylated nonsteroidal antiinflammatory drugs.
Pill-esophagitis caused by nonsteroidal antiinflammatory drugs.
Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs.
Interrelationships between Helicobacter pylori infection, nonsteroidal antiinflammatory drugs and gastroduodenal disease.
PGH synthase isoenzyme selectivity: The potential for safer nonsteroidal antiinflammatory drugs.
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.
Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal antiinflammatory drugs.
Prevention of in vitro neutrophil-endothelial attachment through shedding of L-selectin by nonsteroidal antiinflammatory drugs.
Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events.

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