nonsteroidal anti-inflammatory drug
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nonsteroidal anti-inflammatory drugAny of a family of weak organic acids that
eg, mefanamic acid, enolic acid analogues–eg, oxyphenbutazone, phenylbutazone; nonacidic compounds–eg, proquazone Side effects Rash, pruritus, edema, vertigo, drowsiness, tinnitus, aseptic meningitis, N&V, gastric ulcers, potentially fatal GI hemorrhage, jaundice, Stevens-Johnson syndrome, Henoch-Schönlein syndrome, aplastic anemia, acute renal failure. See NSAID enteropathy.
nonsteroidal anti-inflammatory drugAbbreviation: NSAID
CAUTION!All NSAIDS increase the risk of gastrointestinal bleeding and ulceration and, to some extent, the risk of renal failure, abnormalities in liver function, myocardial infarction, and stroke. These side effects occur most often in older patients, e.g., those with multiple risk factors for atherosclerotic vascular disease.
Many patients experience side effects of these medications, including upper gastrointestinal inflammation or bleeding. These side effects occur most often in the elderly, tobacco users, and those who drink alcohol. Other potential complications include acute and chronic renal failure, liver function abnormalities, and aseptic meningitis.
Members of this class of drugs include aspirin, ibuprofen, and naproxen.
Patients who are sensitive to NSAID therapy are told to inform caregivers so that they will not be given NSAIDs. Patients are instructed to watch for adverse effects when taking NSAIDs and to report any gastrointestinal pain or bleeding. The patient should be cautioned not to take NSAIDs on an empty stomach but with milk, a meal, or an antacid. Skin should be protected from the sun. Pregnant women should avoid NSAIDs during their last trimester.