nonsteroidal anti-inflammatory drug


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nonsteroidal anti-inflammatory drug

Any of a family of weak organic acids that
1. Inhibit prostaglandin biosynthesis, by inhibiting cyclooxygenase, and to a lesser degree lipooxygenase and.
2. Interfere with membrane-bound reactions–eg, NADPH oxidase in neutrophils, phospholipase C in monocytes and G protein-regulated processes Uses Rheumatoid arthritis, gouty arthritis, ankylosing spondylitis, osteoarthritis, serosal inflammation, Bartter syndrome, and other inflammatory conditions Chemical classes Carboxylic acid: acetylated–eg, aspirin–figure or nonacetylated–eg, sodium salicylate; acetic acid analogues–eg, indomethacin, tolmetin, sulindac; propionic acid analogues–eg, ibuprofen, naproxen; fenamic acid analogues–
eg, mefanamic acid, enolic acid analogues–eg, oxyphenbutazone, phenylbutazone; nonacidic compounds–eg, proquazone Side effects Rash, pruritus, edema, vertigo, drowsiness, tinnitus, aseptic meningitis, N&V, gastric ulcers, potentially fatal GI hemorrhage, jaundice, Stevens-Johnson syndrome, Henoch-Schönlein syndrome, aplastic anemia, acute renal failure. See NSAID enteropathy.

nonsteroidal anti-inflammatory drug

Abbreviation: NSAID
A drug that has analgesic, anti-inflammatory, and antipyretic actions. NSAIDs are used to treat acute and chronic pain, e.g., of injuries, arthritis, and dysmenorrhea, to reduce inflammation, and to prevent complications in serious illness such as sepsis.

CAUTION!

All NSAIDS increase the risk of gastrointestinal bleeding and ulceration and, to some extent, the risk of renal failure, abnormalities in liver function, myocardial infarction, and stroke. These side effects occur most often in older patients, e.g., those with multiple risk factors for atherosclerotic vascular disease.

Many patients experience side effects of these medications, including upper gastrointestinal inflammation or bleeding. These side effects occur most often in the elderly, tobacco users, and those who drink alcohol. Other potential complications include acute and chronic renal failure, liver function abnormalities, and aseptic meningitis.

Members of this class of drugs include aspirin, ibuprofen, and naproxen.

Patient care

Patients who are sensitive to NSAID therapy are told to inform caregivers so that they will not be given NSAIDs. Patients are instructed to watch for adverse effects when taking NSAIDs and to report any gastrointestinal pain or bleeding. The patient should be cautioned not to take NSAIDs on an empty stomach but with milk, a meal, or an antacid. Skin should be protected from the sun. Pregnant women should avoid NSAIDs during their last trimester.

See also: drug

Nonsteroidal anti-inflammatory drug (NSAID)

A type of medicine used to relieve pain, swelling, and other symptoms of inflammation, such as ibuprofen or ketoprofen.
Mentioned in: Antiulcer Drugs
References in periodicals archive ?
Nonsteroidal anti-inflammatory drugs or NSAIDs are among the most commonly prescribed medications in the world, (1) and are among the most widely used drugs in the world.
The nonsteroidal anti-inflammatory drugs (NSAIDs) and steroidal anti-inflammatory drugs (SAIDs), on the other hand, inhibit cyclooxygenases, leading to gastric ulceration and perforation when used chronically.
Among study participants, use of narcotic painkillers (hydrocodone, oxycodone, propoxyphene, or codeine) was linked to a 3.7 times greater risk for falls and fractures than use of COX-2 inhibitors (Celebrex) and a 4.4 times greater risk than nonsteroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen, naproxen, and acetaminophen).
compile 28 chapters for scientists and clinicians that detail the process and factors that influence chronic inflammation, outlining the systems biology of inflammation and regulatory mechanisms, including initiation, progression, and resolution; associated pathologies, such as cancer, chronic wounds, scarring, neuroinflammatory disease, autoimmune disease, and vascular inflammation; and nutrition and therapeutics for these diseases, including the protective abilities of structurally diverse antioxidants, phytochemicals, anti-inflammatory diets, omega-3 fatty acids, nonsteroidal anti-inflammatory drugs (NSAIDS), physical activity, disease modifying anti-rheumatic drugs, and novel regimens.
The proportion of women who used nonsteroidal anti-inflammatory drugs for menstrual pain was significantly lower in the vitamin D group than in the placebo group (0% vs.
Their exposure to having been prescribed nonsteroidal anti-inflammatory drugs (NSAIDs) was determined from prescription data.
Washington, Sept 7 (ANI): A new study found that women who took any type and dosage of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) in early pregnancy had a 2.4 times greater risk of miscarriage than those who don't use them.
A team from the Farncombe Family Digestive Health Research Institute has found those stomach acid-reducing drugs, known as proton pump inhibitors, may actually be aggravating damage in the small intestine caused by the nonsteroidal anti-inflammatory drugs, also known as NSAIDs.
Studies continue to show that nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with cardiovascular risks and should be used with care.
Participants' use of pain-relieving medicines known as nonsteroidal anti-Inflammatory drugs (NSAIDS) was recorded along with other information such as age, smoking habits, and diet.
But several panelists at the joint committee meeting of the Arthritis Advisory Committee and Drug Safety and Risk Management Advisory Committee said they were enthusiastic about the concept behind naproxcinod, which was designed to address the blood pressure-elevating effects of nonsteroidal anti-inflammatory drugs (NSAIDs).
Other medication classes studied include hypertensives, diuretics, beta-blockers, and nonsteroidal anti-inflammatory drugs.