nonsteroidal anti-inflammatory drug

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nonsteroidal anti-inflammatory drug

Any of a family of weak organic acids that
1. Inhibit prostaglandin biosynthesis, by inhibiting cyclooxygenase, and to a lesser degree lipooxygenase and.
2. Interfere with membrane-bound reactions–eg, NADPH oxidase in neutrophils, phospholipase C in monocytes and G protein-regulated processes Uses Rheumatoid arthritis, gouty arthritis, ankylosing spondylitis, osteoarthritis, serosal inflammation, Bartter syndrome, and other inflammatory conditions Chemical classes Carboxylic acid: acetylated–eg, aspirin–figure or nonacetylated–eg, sodium salicylate; acetic acid analogues–eg, indomethacin, tolmetin, sulindac; propionic acid analogues–eg, ibuprofen, naproxen; fenamic acid analogues–
eg, mefanamic acid, enolic acid analogues–eg, oxyphenbutazone, phenylbutazone; nonacidic compounds–eg, proquazone Side effects Rash, pruritus, edema, vertigo, drowsiness, tinnitus, aseptic meningitis, N&V, gastric ulcers, potentially fatal GI hemorrhage, jaundice, Stevens-Johnson syndrome, Henoch-Schönlein syndrome, aplastic anemia, acute renal failure. See NSAID enteropathy.

nonsteroidal anti-inflammatory drug

Abbreviation: NSAID
A drug that has analgesic, anti-inflammatory, and antipyretic actions. NSAIDs are used to treat acute and chronic pain, e.g., of injuries, arthritis, and dysmenorrhea, to reduce inflammation, and to prevent complications in serious illness such as sepsis.


All NSAIDS increase the risk of gastrointestinal bleeding and ulceration and, to some extent, the risk of renal failure, abnormalities in liver function, myocardial infarction, and stroke. These side effects occur most often in older patients, e.g., those with multiple risk factors for atherosclerotic vascular disease.

Many patients experience side effects of these medications, including upper gastrointestinal inflammation or bleeding. These side effects occur most often in the elderly, tobacco users, and those who drink alcohol. Other potential complications include acute and chronic renal failure, liver function abnormalities, and aseptic meningitis.

Members of this class of drugs include aspirin, ibuprofen, and naproxen.

Patient care

Patients who are sensitive to NSAID therapy are told to inform caregivers so that they will not be given NSAIDs. Patients are instructed to watch for adverse effects when taking NSAIDs and to report any gastrointestinal pain or bleeding. The patient should be cautioned not to take NSAIDs on an empty stomach but with milk, a meal, or an antacid. Skin should be protected from the sun. Pregnant women should avoid NSAIDs during their last trimester.

See also: drug

Nonsteroidal anti-inflammatory drug (NSAID)

A type of medicine used to relieve pain, swelling, and other symptoms of inflammation, such as ibuprofen or ketoprofen.
Mentioned in: Antiulcer Drugs


1. counteracting or suppressing inflammation.
2. an agent that so acts.

anti-inflammatory drugs
those used to reduce the inflammatory response to infectious agents, trauma, surgical procedures or in musculoskeletal disease.
nonsteroidal anti-inflammatory drug
References in periodicals archive ?
Peptic ulcer and gastrointestinal hemorrhage associated with nonsteroidal anti-inflammatory drug use in patients younger than 65 years.
Hepatotoxicity of nonsteroidal anti-inflammatory drugs.
Role of dose potency in the prediction of risk of myocardial infarction associated with nonsteroidal anti-inflammatory drugs in the general population.
Studies continue to show that nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with cardiovascular risks and should be used with care.
It is particularly problematic in the elderly, who often have concomitant diseases that limit our options for several of the oral medications, particularly nonsteroidal anti-inflammatory drugs and potent analgesics.
Products covered by the FDA action include acetaminophen and a class of drugs knows as the nonsteroidal anti-inflammatory drugs (NSAIDs).
We studied this years ago and found that calcium channel blockers helped alleviate any blood pressure-associated change with nonsteroidal anti-inflammatory drugs," Dr.
Others took either ibuprofen or naproxen, both of which are traditional nonsteroidal anti-inflammatory drugs (NSAIDs).
Acetaminophen doesn't reduce inflammation as do aspirin, ibuprofen, and naproxen, which are called nonsteroidal anti-inflammatory drugs.
OTC IAAA drug products, commonly known as acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, ibuprofen, naproxen and ketoprofen, are used to treat pain, fever, headaches and muscle aches.
Among poultice preparations containing nonsteroidal anti-inflammatory drugs (NSAIDs), it is the first poultice for usage once per day to be granted approval for manufacture.