cholinesterase

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cholinesterase

 [ko″lin-es´ter-ās]
an enzyme that splits acetylcholine into acetic acid and choline; it occurs primarily in the serum, liver, and pancreas. See also acetylcholinesterase.
true cholinesterase acetylcholinesterase.

cho·lin·es·ter·ase

(kō'lin-es'ter-ās),
One of a family of enzymes capable of catalyzing the hydrolysis of acylcholines and a few other compounds. In mammals, found in white matter of brain, liver, heart, pancreas, and serum. It is also found in cobra venom.
See also: acetylcholinesterase.

cholinesterase

(kō′lə-nĕs′tə-rās′, -rāz′)
n.
Any of several enzymes that catalyze the hydrolysis of esters of choline, especially acetylcholinesterase.

cholinesterase

(1) EC 3.1.1.8—synthesized in the liver, present in serum; and
(2) EC 3.1.1.7—acetylcholinesterase, which is synthesised in red cells.

Both enzymes are used to determine the extent of organophosphate exposure; the serum form (EC 3.1.1.8) is more useful in detecting acute toxicity while acetylcholinesterase (EC 3.1.1.7) better reflects chronic exposure.

cholinesterase

There are 2 cholinesterases: one is synthesized in the liver and present in the serum, and the other–now formally known as acetylcholinesterase—is synthesized in the RBCs; both are used to determine the extent of organophosphate exposure; the serum form is more useful in detecting acute toxicity while acetylcholinesterase better reflects chronic exposure; some people have genetic variants of cholinesterase, which act more slowly on substrates than the normal enzyme, and they may experience prolonged apnea after anesthesia with suxamethonium-type muscle relaxants; these variant enzymes can be detected by screening before undergoing anesthesia. See Dibucaine number. Cf Acetylcholinesterase.

cho·lin·es·ter·ase

(ChE) (kō'lin-es'tĕr-ās)
One of a family of enzymes capable of catalyzing the hydrolysis of acylcholines and a few other compounds. Found in cobra venom.

cholinesterase

An enzyme that rapidly breaks down acetylcholine to acetic acid and choline so that its action as a NEUROTRANSMITTER ceases.

cholinesterase

an enzyme that hydrolyses and destroys excess ACETYLCHOLINE after it has been liberated and has produced its effect on specific sites on the postsynaptic membrane at a nerve synapse. See NERVE IMPULSE.

cho·lin·es·ter·ase

(kō'lin-es'tĕr-ās)
One of a family of enzymes capable of catalyzing the hydrolysis of acylcholines and a few other compounds. In mammals, found in white matter of brain, liver, heart, pancreas, and serum.
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