Reality: There is no evidence that nonsedating
antihistamines are beneficial unless the patient has concurrent rhinoconjunctivitis, so data don't support their use "for the actual itch of eczema," Dr.
Furthermore, the newer agents are comparatively nonsedating
, thus providing further benefit over older antihistamines with sedatives properties that are no longer recommended in adults or children.
KYOTO, JAPAN -- Fexofenadine is the sole truly nonsedating
antihistamine--and the only one that does not cause objectively measurable cognitive and psychomotor impairment at doses commonly used in clinical practice, said Dr.
2) While sleep disturbance, chronic inflammation, psychological problems, and other proposed etiologies probably contribute to CRS-related fatigue, recent evidence suggests that nonsedating
antihistamines might add to the burden.
a British supplier that has been supplying pharmacies across the world with homeopathic medicines for 140 years, last fall introduced Rescue Remedy, an all-natural stress reliever, and Rescue Sleep, a nonsedating
sleep aid, as its first products for the mass market.
As an example, when the nonsedating
antihistamine terfenadine was commercially available, certain "azole" antifungal agents had the potential to increase concentrations of terfenadine by inhibiting its metabolism thus increasing the prevalence of terfenadine side effects (eg, QT prolongation).
An FDA advisory committee agreed with WellPoint, voting 19-4 that nonsedating
antihistamines like Claritin, Aventis SA's Allegra, and Pfizer's Zyrtec were sufficiently safe and effective for over-the-counter consumption.
In 2002, Claritin--the most-prescribed nonsedating
antihistamine now on the market--was approved for OTC sales for allergic rhinitis symptoms.
Millions of dollars are spent every year on prescriptions for nasal corticosteroids and nonsedating
antihistamines given to patients who do not have allergic disease.
In 2002, a study in Sweden noted that among male infants born to women who while pregnant had taken loratadine (Claritin[R]), a nonsedating
antihistamine commonly used for seasonal allergies, hypospadias prevalence was twice that of the general population (1).
MEDICATE: Regular antihistamines are available over the counter, and nonsedating
antihistamines, such as Claritin and Allegra, are available by prescription.
Nonsteroidal anti-inflmnmatory drugs, such as ibuprofen, may help get rid of any body aches or fever, and nonsedating
antihistamines may help relieve any prominent allergic symptoms, such as numy nose.