(The sedating antihistamines prescribed included hydroxyzine, diphenhydramine, chlorphenirarnine, brompheniramine, and cyproheptadine; nonsedating
antihistamines include cetirizine, desloratadine, levoce-tirizine, loratadine, and fexofenadine.)
Effects of sedating and nonsedating
antihistamines on flying performance.
Reality: There is no evidence that nonsedating
antihistamines are beneficial unless the patient has concurrent rhinoconjunctivitis, so data don't support their use "for the actual itch of eczema," Dr.
Fexofenadine, an orally active nonsedating
[H.sub.1]-receptor antagonist prescribed for oral treatment of allergic rhinitis and chronic idiopathic urticaria has been shown to be a substrate of P-glycoprotein (P-gp) [9-11].
An acquaintance who suffered for years with widespread eczema finally found relief last year when her doctor suggested she try taking a nonsedating
antihistamine, like loratadine (Claritin), fexofenadine (Allegra) or cetirizine (Zyrtec).
(16) It suggests a nonsedating
SSRI, followed by a trial of methylphenidate, pemoline, or dextroamphetamine if SSRIs were unsuccessful.
Desloratadine is a potent, nonsedating
antihistamine with anti-inflammatory properties.
There is no evidence to support the use of nonsedating
antihistamines in the treatment of AD.
A positive response did not require patients to discontinue nonsedating
antihistamines previously in regular use.
Eplivanserin is the furthest along in development of a new nonsedating
drug class known as ASTARs, or Antagonists of Serotonin Two A Receptors.
KYOTO, JAPAN -- Fexofenadine is the sole truly nonsedating
antihistamine--and the only one that does not cause objectively measurable cognitive and psychomotor impairment at doses commonly used in clinical practice, said Dr.
(2) While sleep disturbance, chronic inflammation, psychological problems, and other proposed etiologies probably contribute to CRS-related fatigue, recent evidence suggests that nonsedating
antihistamines might add to the burden.