nonsecretor


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nonsecretor

 [non″se-kre´tor]
a person with A or B type blood whose body secretions do not contain the particular (A or B) substance.

non·se·cre·tor

(non'sē-krē'tŏr, -tōr),
An individual with saliva that does not contain antigens of the ABO blood group.
See also: secretor.

nonsecretor

/non·se·cre·tor/ (non″sĭ-krēt´er) a person with A or B type blood whose body secretions do not contain the particular (A or B) substance.

nonsecretor

[-səkrē′tər]
Etymology: L, non + secernere, to separate
a person who does not secrete ABO blood group substances in mucous secretions of the saliva or gastric juice. The condition is genetically determined.

non·se·cre·tor

(non'sĕ-krē'tŏr)
A person whose saliva does not contain antigens of the ABO blood group.
See also: secretor
References in periodicals archive ?
Approximately 20% of the white population is homozygous for a recessive point mutation of the FUT2 gene, which leads to the absence of A, B, and H antigen expression, also called the nonsecretor phenotype.
Recently, the Lewis gene (FUT3) and the secretor gene (FUT2) were cloned (2, 3), and several silent alleles that cause the Lewis-negative (4-9) and the nonsecretor (1015) phenotypes, respectively, were identified.
Persons with a nonsecretor gene (FUT2-/-) represent as much as 20% of the European population.
On the basis of a comparison of Ca 19-9 in nonsecretor and secretor patients, ignoring non-significant differences in tumor stage and grade between the two groups, an examination of Ca 19-9 ratios showed a considerably higher concentration (P <0.
Splenocytes were fused with a nonsecretor cell line sp2/0 and plated into Dulbecco's modified Eagle's medium containing hypoxanthine, aminopterin, and thymidine with 150 mL/L fetal bovine serum.
Moreover, a non-sense mutation in the fucosyltransferase gene 2 (FUT2), which gives rise to the nonsecretor phenotype, has been found to provide almost complete protection from experimental and natural NoV infection (2,3).
None of the strains recognized nonsecretor saliva, which showed that binding to human saliva required A, B, or H motifs.
4 strains have been found to mainly bind saliva from secretors irrespective of blood group (16), although binding to nonsecretor saliva has been described for VLPs of some GII.
However, after incubation with type B secretor saliva or nonsecretor saliva, binding was as strong as that observed in positive controls (Table 1).
It's reliable in nonsecretors and in patients with extramedullary relapse, and it effectively monitors abnormally behaving myeloma, they wrote.
Persons who lack a functional FUT2 gene cannot generate ABH antigens in secretions and, thus, are termed nonsecretors (23,24).
The latter theory has been supported by the discovery that different norovirus strains may have different histo-blood group antigen (HBGA) binding patterns and that nonsecretors are not susceptible to infection with certain genotypes or variants (23).