Homozygous secretor, heterozygous secretor, and nonsecretor genotypes represented 23.
Our findings show that rotaviruses can infect secretor and nonsecretor Lewis antigen-positive persons, which suggests that rotavirus infection is not associated with the secretor phenotype or HBGA type.
1), nonsecretor individuals have more CA 19-9 in their serum and urine than secretor individuals (23).
The coding sequence of FUT2 was sequenced completely in one nonsecretor individual and partially in two secretor-positive individuals.
they have the nonsecretor
phenotype), and therefore play no role in the transmission process (Figure 1) (18).
Positive controls for the detecting antibodies consisted of urine obtained from apparently healthy adults, typed as secretors and nonsecretors
, respectively, on fresh blood samples, by standard agglutination methods performed in a specialized blood grouping laboratory at Aarhus University Hospital (Skejby, Denmark).
However, in contrast to the case with NoV, neither the G428A nonsecretor
mutation, nor any of the ABO blood groups or Lewis phenotypes protected children against SaV infection.
n = 8), A secretor Lewis+ (n = 3), B secretor Lewis+ (n = 2), O secretor Lewis- (n = 1), and O nonsecretor
Lewis+ (n = 4).
We describe a foodborne NoV outbreak in which persons were infected regardless of secretor status or Le phenotypes; and no difference was observed between nonsecretor
samples tested VLP binding * A 14 - O 18 + B 4 +++ Nonsecretor
5 +++ Control 5 +++ * After incubation with saliva, no (-), weak (+), or strong (+++) VLP binding to oyster digestive tissues was observed.
Persons who lack a functional FUT2 gene cannot generate ABH antigens in secretions and, thus, are termed nonsecretors
The latter theory has been supported by the discovery that different norovirus strains may have different histo-blood group antigen (HBGA) binding patterns and that nonsecretors
are not susceptible to infection with certain genotypes or variants (23).