Not leading to the production of proteins.
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Target molecules will be chiral pharmaceutically active ingredients, Or immediate precursors, Including nonproteogenic alfa-disubstituted-amino acids.
[beta]-alanine is a nonessential and nonproteogenic amino acid that is synthesized in the liver (10).
As for urotensin peptides, substitution of natural amino acid residues by unnatural amino acid such as D-stereoisomer, nonproteogenic constrained amino acid or [beta]-amino acid has represented strategic chemical approach resulting in the increase of stability and/or affinity for the UT receptor.